Reactive Oxygen Species and Molecular Targets: Review on Diabetic Nephropathy

Abstract: Diabetes mellitus is a metabolic disorder known to cause retinopathy, neuropathy and nephropathy. Diabetic nephropathy is a persisting major microvascular complication of uncontrolled hyperglycemia that affects a large number of people worldwide. Recent studies suggest that numerous pathways are activated during the course of diabetes mellitus and these pathways individually or collectively play a role in the induction and progression of diabetic nephropathy. However, clinical approaches targeting these pathways to manage diabetic nephropathy remain inadequate, as the number of diabetic patients with nephropathy is increasing yearly. For the development of new and effective therapeutic options to prevent the induction and progression of diabetic nephropathy, an ample understanding of the molecular mechanisms involved in the pathogenesis of the disease is obligatory. Thus, the purpose of this paper is to discuss the underlying mechanisms and downstream pathways involved in the pathogenesis of diabetic nephropathy.

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[Viplove Kataria, Shamsher Singh, Jatin Sharma, Avi Gupta and Sunil Bansal (2015); Reactive Oxygen Species and Molecular Targets: Review on Diabetic Nephropathy Int. J. of Adv. Res. 3 (4). 0] (ISSN 2320-5407). www.journalijar.com

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