Prevalence of Micronucleated Cell in Buccal Smears among Smokers and Non-smokers
Abstract: Tobacco addiction is responsible for the huge increase in diseases such as cancer and heart problems. One of the major constituents of environmental toxins is tobacco smoke which is responsible for deaths throughout the world. The process of aberrant mitosis gives rise to micronucleus. Micronucleus is a cytoplasmic chromatin mass which is either oval or round in shape and is visible through a microscope. The buccal cell MN assay has generated enough international interest which has caused the Human Micronucleus project (HUMN) to initiate a new project to validate it. The oral tissues suffer severe damage due to the oral smoking of tobacco on a continuous basis. Smears are a pivotal method for the determination of the damage caused to the oral tissues due to tobacco smoke. Smears help detect the micronuclei in the exfoliated cells of the oral tissue to determine the damage. Our study helped determine the direct impact of tobacco smoke on the cytogen (micronuclei). The study examined 100 individuals who included active, passive and non-smokers. F-test was used as a statistical tool for analysis. The analysis showed that smokers had a higher count of micronuclei per 100 cell counts in comparison to the non-smokers. The results signified a direct relation between the existence of number of micronuclei to that of the tobacco habits of the smokers including the frequency and duration of smoking. Besides, the study also showed an apparent increase in the MN count in the middle age segment of the participants.
[Kewan Kamal Ahmad, Saifadin Khder Mustafa, Karim Jalal Karim (2015); Prevalence of Micronucleated Cell in Buccal Smears among Smokers and Non-smokers Int. J. of Adv. Res. 3 (4). 0] (ISSN 2320-5407). www.journalijar.com
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