28Feb 2014

Effect of blue green algae on some biochemical and hematological markers in mice

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Blue-green algae (BGA) are among the most primitive living organisms on Earth. The present work was conducted to assess the effect of BGA (Aphanizomenon flos-aquae) on some biochemical and hematological markers in male albino mice. Results revealed that oral administration of 100mg/kg of BGA for 15 consecutive days led to a very high significant elevation (P<0.0001) in hepatic catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) and glutathione peroxidase (GPX) activities as compared to those of the normal controls. In contrast, the level of hepatic lipid peroxidation, measured as malondialdehyde (MDA) was very high significantly decreased (P<0.0001) in mice treated with BGA. Meanwhile, the treatment of mice with BGA for 15 days did not exhibit a toxic effect on the liver and kidney. Also, oral administration of BGA for 15 days significantly increased the number of RBCs (P<0.05) and very high increased (P<0.0001) in the values of RBCs, Hb, PCV and platelets as compared to those of the controls. In conclusion, BGA can induce the generation of antioxidant enzymes with no harmful side effect on both liver and kidney and helps in improvement of the hematological markers.


[Alshimaa M. Elmalawany, Tarek A. Salem, Azza H. Mohamed and Gamalat Y. Osman (2014); Effect of blue green algae on some biochemical and hematological markers in mice Int. J. of Adv. Res. 2 (2). 0] (ISSN 2320-5407). www.journalijar.com


Alshimaa M Elmalawany


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