Aluminium induced cholinotoxicity in zebra fish brain - A sequel of oxidative stress

Abstract: Aluminium has been reported to have biological effects that make the organism’s health in jeopardy when the exposure exceeds the adaptive capability. Exposure to aluminium chloride for 21 days has been found to alter Acetylcholinesterase (AChE) activity and oxidative status in brain tissue of zebra fish in the present study. When groups of zebrafish were exposed to non-lethal concentration of AlCl3, there was an increasing trend in the activity of the enzyme AChE up to 14 days. As the enzyme is vital in the hydrolysis of the neurotransmitter Acetylcholine (ACh) which plays an important role not only in neurotransmission but also in the behaviour of the animal, this observation can have a serious implication on the survival of the animal. The oxidative stress assessed by Lipid peroxidation (LPO) is also found to be increased. The response of tissue antioxidants assessed by glutathione s-transferase (GST), Catalase and reduced glutathione (GSH) varied in animals exposed to AlCl3 for different durations. While some of the responses of the antioxidants correlate with the extent of free radicals produced as assessed by LPO, the importance of correlating this response to alterations in the AChE has been discussed.

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[S.L.Maheswari , R.Venkatakrishna Murali , and R.Balaji (2014); Aluminium induced cholinotoxicity in zebra fish brain - A sequel of oxidative stress Int. J. of Adv. Res. 2 (2). 0] (ISSN 2320-5407). www.journalijar.com

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