Immunotoxicity of sub-chronic doses of diazinon in male albino Wister rats

Abstract: Diazinon is one of the most organophosphate pesticides that widely used in agriculture. In the current study, diazinon was administrated at doses of 10, 1, 0.1mg/kg and different humoral and cell mediated immunity parameters were examined in male Wister rats. Results showed that high dose of diazinon (10mg/kg) could inhibit the hemagglutination titer, the total serum immunoglobulin, quantitative hemolysis of SRBC (QHS), phagocytic function of neutrophils, delayed-type hypersensitivity response, proliferative response of the blood mononuclear cell and decrease the percentage of CD4+ and CD8+ blood mononuclear cells without affecting CD4/CD8 ratio significantly. Diazinon at moderate dose (1mg/kg) show only reduction in QHS, phagocytic function of neutrophils and delayed-type hypersensitivity response. Diazinon at low dose (0.1mg/kg) did not produce any significant changes on the humoral and cellular immune tested parameters. In conclusion high dose of diazinon affect both humoral and cell-mediated immunity in rats. On contrary, low dose of diazinon has no adverse effect on the immune response.

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[Hany Mohammed Ibrahim (2014); Immunotoxicity of sub-chronic doses of diazinon in male albino Wister rats Int. J. of Adv. Res. 2 (2). 0] (ISSN 2320-5407). www.journalijar.com

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