30Jun 2016

Lipid peroxidationand antioxidant statusin overt and subclinical hypothyroidism

  • Internal Medicine Department,Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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Background: Oxidative stress, caused by an imbalance in reactive oxygen species produced during normal cell metabolism and/or deficiency of scavenger antioxidant defense, has been implicated in the pathology of several human diseases, including endocrine diseases of thyroid gland. Aim of the work: The aim of this study is to evaluate the serum levels of malondialdehyde (MDA), a product of lipid peroxidation, and the antioxidant enzymatic activities of superoxide dismutase (SOD) and catalase (CAT) as well as the total antioxidant capacity (TAC) in overt and subclinical hypothyroidism. Subjects and methods: Forty eight newly diagnosed hypothyroid patients, 24 patients of them have subclinical hypothyroidism (SHT) while the other 24 patients have overt hypothyroidism (OHT), as well as 24 healthy euthyroid control subjects were enrolled in this cross sectional study. Laboratory investigations including lipid profile, thyroid functions as well as levels of serum MDA, SOD, catalase and TAC were estimated. Results: Both OHT and SHT patients had significantly higher serum TSH, total cholesterol (TC), triglycerides (TGs), LDL-C, catalase, SOD and MDA levels as well as significantly lower serum HDL-C and TAC levels when compared to euthyroid control subjects. The correlation study revealed that serum TSH levels were significantly positively correlated with TC, LDL-C and TGs serum levels and significantly negatively correlated with HDL-C levels. Moreover, serumMDA, CAT and SOD levels showed significantly positive correlation with TSH, TC, LDL-C and TGs serum levels and a significant negative correlation with free T4, free T3 and HDL-C serum levels.Furthermore, TAC levels showed a significant positive correlation with free T4, free T3 and HDL-C serum levels and a negative correlation with TSH, TC, TGs and LDL- C serum levels. Conclusions: The present study demonstrated that patients with both OHT and SHT showed increased lipid peroxidation and oxidative stress which was evidenced by the increased levels of MDA, a lipid peroxidation product, and the induction of SOD and CAT antioxidantenzymatic activities. Increased MDA and other free radical production could overload the antioxidant system resulting in consumption and severe depletion of antioxidants with concomitant reduction in total antioxidant capacity.


[Hamed A. Deraz, Amira Shoukry, Hoda G. Bakr, and Sally M. Shalaby. (2016); Lipid peroxidationand antioxidant statusin overt and subclinical hypothyroidism Int. J. of Adv. Res. 4 (6). 322-332] (ISSN 2320-5407). www.journalijar.com


Amira Shoukry


DOI:


Article DOI: 10.21474/IJAR01/652       DOI URL: http://dx.doi.org/10.21474/IJAR01/652


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