Cu AND Mn COMPLEXES OF NICOTINIC ACID AND IMIDAZOLE: A CURRENT REVIEW

* Shakeel Ahmad Khan 1 , Sadia Kanwal 2 , Ahsan Iqbal 3 and Waqar Ahmad 1 . 1. Department of Chemistry, University of Management and Technology Lahore-54000, Pakistan. 2. Department of Biochemistry, University of Agriculture Faislabad-38000, Pakistan. 3. Department of Chemistry, GC University, Faisalabad-38000, Pakistan. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History


ISSN: 2320-5407
Int. J. Adv. Res. 5 (4), 1350-1368 1351 many enzymes like oxidoreductase, transferases, hydrolases, isomerases etc. Mn in excess causes problem. It leads to the condition called as neurodegenerative disorder and it may cause death [6]. Daily intake of Mn with food is 2.3 mg per day for males and less for females. Most of Mn is stored in bones and left of it in liver, kidney and soft tissues of body. During photosynthesis, it also play important role in chloroplast of plants. Fatal dose of Mn is 10 g. It affects cognitive and motor skills. It also effect mucus membrane by necrosis, kidney, liver etc. Weakness, slow speech, rigidity, expression less face etc. are all symptoms to increased level of Mn in body [7]. Imidazole is an organic compound having molecular formula C 3 H 4 N 2 and melting point 89-91 ºC. It is colorless solid and polar compound with protons on the either sides of two N-atoms. It has six π-electrons show resonance and is amphoteric. Imidazole is important component of many natural products and pharmacological molecules. Its ring acts as good ligand with transition metal atoms and performs number of biological functions like inhibiting growth of tumor [8]. It is used for the treatment of fungal infections and present in fungicides, antifungal, antiprotozoal, anticancer, antibacterial, anti-inflammatory and antihypertensive medicines. It combats leukemia by interaction with DNA [9].
Nicotinic acid is an organic compound also known as vitamin B 3. It is colorless, water soluble solid having molecular formula C 6 H 5 NO 2 and melting point 237 º C. It is derivative of pyridine with carboxyl group at 3position.Insufficient Nicotinic acid cause diseases like anemia, headache, tiredness, nausea, skin infection. Its chronic deficiency causes pellagra. Nicotinic acid is useful in minimizing the chances of cardiovascular diseases [10]. Niacin is found in many foods i.e. chicken, beef, fish, peanuts. High dose of Niacin cause toxic effect like maculopathy (thickening of retina) which causes blindness [11]. It also causes elevation of blood sugar, Diabetes mellitus [12].
Metal Complexes of Nicotinic Acid and Imidazole:-Cu +2 Complexes with Nicotinic acid:-It was stated that complexes of mixed ligand nicotinic acid with other carboxylic acids were synthesized. Studies showed that nicotinic acid or vitamin B 3 was used as physiological and anti-hyper lipidemic functions. Cu complexes were tested and observed antimicrobial activity against Bacillus subtilis with 256µg/ mL that was minimum inhibition concentration. Cu complexes also showed super oxide dismutase (SOD) mimetic activity. Cu complex with maximum SOD activity possess highest occupied molecular orbital energy (HOMO). These properties showed potential for development of metallo vitamin based medicine [13].  characterize and investigate thermal behavior of these compounds. Investigation of thermal behavior of nicotinic acid and its sodium salt was also done. The hydrated transition metal compounds were dehydrated and thermally decomposed in a single step. Different results such as the thermal stability, thermal decomposition and identification of the gaseous products formed in the process of decomposition of the compounds were found [14].
It was studied that copper nicotinic acid complex was used to treat fatty liver in which fat stores in cells of liver and caused problem in structure and functions of liver. It was applied on fatty liver of rat model. Cu nicotinate complex was applied for 4 weeks. Improvements were observed in rats. Fat droplets disappeared from liver sections. Liver weight, liver trans aminases and alkaline phosphates were decreased and nitric oxides, super oxides; lipid peroxides were changed to normal level. Cu complex was important for renewal of structure and functions [15].
Cu +2 complexes with imidazole:-It was stated that Mn, Cu and Zn complexes with a family of bis-imidazole ligands were synthesized. X-ray crystallography was used to characterize these complexes. A single spacer tetrahedral carbon atom was present between two imidazole rings and formed stable six membered rings having N and NO with metals [16]. Two coordination polymers by using hydrothermal conditions were synthesized. Complexes [Cu(ip)(Him) 2 (DMF)] H 2 O (4) and Co(ip)(Him) 2 (5), (ip = isophthalate, Him = imidazole) has been analyzed by using single X-ray diffraction method and it showed that 1D zigzag of metal-organic chains interlinked through hydrogen bonding and (p-p) interactions to form 3-D structure. By using elemental analysis, IR and UV-VIS techniques were used for the characterization of synthesized complexes. Anti-ferromagnetic interaction was observed in magnetic centers of complex 2 through results [17]. Complexes were prepared by using 1-(3-Aminopropyl) imidazole (Apim) and salicylaldehyde. Schiff based ligands and imidazole aldehydes coordinate with metals (Zn (II), Cu (II) and Ag (I). Crystal structures of Silver (I) complex and two free ligands were formed. Cu (II), Zn (II) and their free ligands showed inactive nature against microbial pathogens. Anti-bacterial and good anti-fungal activity was shown by Ag (I) complexes [18]. Two one dimensional compounds of Cu (II) and Co (II) were prepared and analyzed; Complex 7 was formed by linear trinuclear Cu (II) subunits and µ-hydroxo and µ-carboxylato bridges that showed that there was strong intratrimer anti ferromagnetic and weak inter-trimer anti ferromagnetic coupling with 2.011g value [19].Four complexes of Cu(II) with imidazole having formulas Cu (CH 2 = CH-COO) 2 (imH) 2 (8), Cu 2 (CH 2 = CH-COO) 4 (9), Cu [CH 2 = C(CH 3 )-COO] 2 (imH) 2 (10) and (11) (where imH= imidazole) were synthesized.IR, ESR and electronic reflectance spectroscopies were used for characterization. In complex 10 single crystal X-ray diffraction showed that, Cu was central atom of square planar structure in Tran's position with two αmethacrylate groups that were monodentate and two ligands of imidazole. Two dimensional supramolecular compounds were formed by linkage of neighboring units by hydrogen bonding. Complex 8 and 10 were same, but 9 and 11 were having structure of binuclear cage. In 9, 11 complexes, spin coupling between unpaired electrons of Cu atom were observed but not in complex 8 and 10. Complex 9, 11 showed square planar geometry while 8, 10 showed tetragonal. All these four complexes were synthesized by reaction of Cu(II) imidazole and carboxylate in methanol [20].
1354 It was stated that complexes of Cu like {Bis[(heterocycle)ethyl]amine)copper was formed by the reaction of at least imidazole with 0.5 equivalent dioxygen having 78•C and give peroxo complex containing purple color. Above mentioned complexes having pyridine as well as imidazole donors and they shows absorbing capacity at 538 nm, 435 nm and 332 nm. It was not reactive at low temperature with acid and triphenylphosphme. X-ray crystallography shown structure of its complex and has T-shaped structure [21]. It was stated that Cu (ІІ) complexes were synthesized with imidazole. Complex [Cu (asp)-L,J was formed where asp was anion of aspirinate. Different techniques like elemental analysis, magnetic moments and IR and ESR spectroscopy techniques were used for the characterization of that compound. Tetrakis compound containing imidazole and N-methyl imidazole showed tetragonal six coordinated structure with (CuN4 + 0) chromophore. Tetragonal distorted octahedron geometry was shown by bis adduct of 1, 2-dimethyl imidazole, with CuN 2 O 2 chromophore at Trans distorted square planar environment. Rather than dimeric structure, monomeric structure was discussed due to electronic and steric effects of imidazole ligands [22].
The crystal formation and different temperatures and analysis of magnetic property associated with new thiocyanato based copper(II) complex with bi-imidazole, may be 2-(20-pyridyl)imidazole) (pyim) seeing that co-ligands, usually reported. Complex 1 contains tri-nuclear variety central cations as well as peripheral anions usually were linked through individual bridges of thiocyanate. Complexes 2 and 3 were comprised of neutral copper (II) ion snow chains with one (2) and two (3) bridges of thiocyanato. By the formation of coordination sphere, each copper atom attached with bidentate and N-Donor thiocyanate group. The values of intra-molecular (1) and also intra-chain (2 and also 3) copper to copper separation usually found in the range of 5. 6143, 5. 6744 and 6.0797 Å. Magnetic susceptibility proportions for 1-3 within the temperature range 1.9-295 E showed the phenomenon of weak intramolecular and also intra-chains anti-ferromagnetic interactions. The nature as well as magnitude of magnetic interactions were elaborated with respect to particular respective structures and compared these with those who mentioned for linked system [23].
1355 intricate showed a ferromagnetic coupling of copper (II)-radical i.e., (J = +75 cm−1) while to the other mononuclear chemical substances, mostly with manganese (II), anti-fero-magnetic interactions of metal-radical. Complexes of manganese (II) were one and two-dimensional which showed effects that lead to very weak ferromagnetism. Ions of lanthanide were trivalent such as La(III), Gd(III) along with Eu(III), regarding uninuclear compounds were formed that center of metal was bound to nitroxide radicals along with ancillary ligands. Unexpectedly, Gd(III) radical communications were found as an anti-ferromagnetic in contrast with others, founding along with previously determined theoretical products. Through magnetic studies, properties of Optics for lanthanide compounds have been determined and shortly explained [24]. For the formation of coordination and hydrogen bond, Cu-complexes and Schiff based ligands which were usually composed of imidazole groups which also having a specifically donor as well as acceptor character. They function as ligands or sometimes as self-complementary towards the construction of specific structures forming various hydrogen or possibly coordination bonds. For such type of complexes, monomers were stabilized themselves like protonated species in acidic media, while in basic media, synthesized N-donor imidazole which show coordination with Cu ions bonded with hydrogen bond with their adjacent imidazole group showing specific coordination with different ligands attached with central metal ion. By adjusting pH, a monomer and an oligomer were reversible or an interconvertible with each other [25].
Stable complexes of 3d metals such as Mn (II), Cu (II), Co (II), Ni (II) and Cr (III) with ligands like PEF (Pefloxacin) and imidazole had been prepared. These were characterized by using techniques like X-ray crystallography, FT-IR and other elemental analysis. Their magnetic properties were also explained. The results shown that Pefloxacin behaved like a bidentate ligand and the metal ions from the pyridone oxygen also sometimes from the oxygen of carboxylic group besides for the complex of silver (I), the place that the metal ion chelating towards the nitrogen of piperazinyl. TGA and DTA were the thermal behaviors that had also been also performed around the complexes so that you can study their stabilities as well as activation energies, DE, entropies DS; enthalpies DH and Horowitz-Metzeger procedure calculations were used to know order of reactions n. The mixed ligands processes were determined with regards to antibacterial activity in opposition to two species of bacteria, named as Staphylococcus aureus and Escherichia coli. Antifungal verification was explained in opposition to two species (Aspergillus flavus as well as Candida albicans). These compounds s under study were known [26].
A pair of sandwich-type complexes Na 9n (Cu(imi) 4 A supramolecular arrangement had been synthesized by p-sulfonat othiacalix [4]are or copper(II)/imidazole by hydrogen bonding. It showed that p-sulfonato thiacalix [4]are using 1, 2-oppositearrangement may attach copper(II) along with a bis-tridentate coordination method, and moreover exhibits behavior of charge-transfer [28]. The binuclear complex of copper (II) (complex 1) along with taurine Schiff bottom and imidazole have been prepared and its structure was seen as X-ray diffraction techniques, necessary analysis, ESI-MS spectrometry, UVvis as well as IR spectroscopy. Single-crystal examination showed that 1 demonstrated the sulfonate-bridged dinuclear copper (II) stores. Two copper atoms were usually five-coordinated and demonstrate a little distorted square pyramidal geometry. All copper atoms were actually attached with three oxygen atoms as well as one atom of nitrogen by different ligands of taurine Schiff bottom, and one atom of nitrogen from imidazole ligand. The actual association between 1 as well as (CT-DNA) seemed to be analyzed by UV-Vis spectroscopy, fluorescence, round dichroism (CD) spectra as well as electrophoresis of agarose gel. Actual results pointed out that 1 could possibly bind to CT-DNA by using an inter-connective method and showed effective cleavage activity. In addition, 1 gave an antitumor effect on cell cycle as well as apoptosis. Cytometric flow of examination showed that MGC-803 cells were catched from the S phase following treatment by 1. Fluorescence tiny observation showed which one could produce apoptosis of MGC-803 solar cells [29].
Being unfaithful complex of monoanionic a-hydroxy carboxylates (HL0) using imidazole as a co-ligand has also been synthesized and structurally seen as an X-ray diffraction technique.  (9), containing two non-coordinated benzylate items. In most with the complexes the a-hydroxy carboxylato ligands work as bidentate monoanionic methods, apart from throughout 3, where one particular ligand was uni-dentate. All of the complexes were expanded in frameworks of 2D as well as 3D by way of hydrogen bonding. These compounds were seen as an elemental analysis, FT-IR in addition to UV spectroscopy. Nickel in 1358 addition to copper complexes had been also studied simply at room temperature permanent magnet susceptibility and temperature ESR spectra were obtained with the copper complexes. Ultimately, all the so-called complexes were investigated thermally [30]. 1.5H 2 O} n (1) and also [Co(Pht)(Imi) 2 ]n (2) (where Pht 2 = dianion connected with o= phthalic acid and Imi = imidazole) happen to be prepared and structures of their crystals were dependent upon X-ray crystallographic technique. The structures of just one and two consist of [Cu(Imi) 2 ] and also [Co(Imi) 2 ] units respectively, connected by bridging 1, 6-phthalate ions to form long chains. There were two Cu atoms that were independent inside structure1; each and every copper (II) center explores an almost rectangular planar mode of coordination with two atoms from diverse phthalate ions and also two atoms of N connected with Imi. In complex 2, cobalt (II) atoms usually were coordinated tetrahedrally. The three-dimensional constructions were stabilized by long hydrogen bonding in both processes. Preliminary results show that catalytic activity within the oxidation of cyclohexene was shown by one and two exhibiting utilizing hydrogen peroxide while oxidant under cardiovascular conditions at optimum temperature [31].
Raman spectra were actually formed for ligands like imidazole, histidine, imidazolium and Cu complexes of imidazole on 229 nm to 200 nm wavelengths. It was offered by Raman shifted laser beam. In all events, maximum excitation was showed on -218 nm and -204 nm, inside broad absorption digital band at -210-nm. By the use of ring enhancement patterns, r-r* transitions in the ring of imidazole were identified. Alternations connected with band of Raman frequencies and also intensities were shown. When imidazole was protonated or substituted that has functional group of methyl. Methyl imidazole spectra's and histidine spectra's were same. There was inferior effect on complex of Cu +2 with imidazole. Some wave numbers shifted the ring modes. Change of charge transfer of Cu +2 was placed close to 240 nm. N-Cu stretches mode of enhancement were comparable to that of Cu and (ethylenediamine)? + Which included its charge-transfer band at that wavelength? The enhancement of the 950-cm-' mode of ring was additionally observed at 240 nm. Tries to attain R-R spectra in your neighborhood (-300 nm) of the weakest imidazole (r): Cu 2+ charge-transfer changes were not successful. But differences inside positions of the band might be used to differentiate between protonated, un-protonated, and also Cu-bounded histidine residues with proteins, all round enhancement was normal, and histidine impulses were impossible to detect inside presence of the higher signals from aromatic rings which can exist in many proteins, as it was explained with regards to the Cu proteins stellacyanin [32].
Several din-uclear copper (II) complexes that were acetato-bridged with 5-nitroimidazoles (CuAcNtrim) as well as the known copper-acetato-metronidazole were already synthesized by the route of friendly environment along with spectroscopic characterization. The Cu-AcNtrim compounds of formula [Cu 2 (l-O 2 CCH 3 ) 4 Ntrim 2 ], exactly where Ntrim = metronidazole (1), secnidazole (2), tinidazole (3) or perhaps nimorazole (4), showed dimeric copperacetato paddle-wheel setted up with Ntrim that was axial ligands synchronized to copper(II) ions by the N 3 atoms from the rings of imidazole. EPR data point out behavior that was antiferromagnetic due to that novel series of copper complexes. With the increase in basicity from the Ntrim terminal ligand the coupling constant may be found to decrease. The Cu-Ac-Ntrim complexes as well as the correspondent Ntrim parent drugs showed radio sensitizer 1359 properties regarding Hep2 (human larynx cancer) mobile line in vitro. The better enhancement of radio sensitizer exercise upon coordination to the Ntrim drug to copper(II)has the strongest Cu-Ntrim connection may be found for your nimorazole compound and it exhibited the best lipophilicity within the association of Cu-Ac Ntrim complexes [33].

(Nimim) 2 ] (4)
The catalytic activity of a special Cu-salen variety complex in N-arylation involving arylboronic acids with water and anilines was reported here. This protocol was located to be favorable for many electronically improved aryl boronic acids and also anilines with good output of the isolated product. Additional the scope with this protocol has been spread towards the formation of several N-aryl imidazoles with iso-propanol ligand [34].

Mn +2 complexes with nicotinic acid:-
Complex of nicotinic acid with manganese in sodium Meta silicate ligand was formed and single crystal X-ray diffraction technique was used for structure determination. There were different dimensions of cell in space group for complex crystal. 3D complex was obtained by bridging carboxylate group with two central metal atoms. Intermolecular hydrogen bonds stabilized the crystal structure. FT-IR spectral studies were used for the identification of functional groups and the bonding sites of the ligand with metal atoms. Thermal properties and stability of crystals were known by TGA and DTA [35]. Hetero metallic complex, [Ni 2 Mn (N 3 ) 2 (nic) 4 -(H 2 O) 2 ]n where nic =nicotinate) was also prepared. It was formed by using MnCl 2 .4H 2 O, Ni (NO 3 ) 2 .6H 2 O, NaN 3 and nicotinic acid by "one step" method. Ni-Mn-Ni was used to describe 3Dstructure of the complex and nicotinate linked that trimer [36] (Jiaoet al., 2013). Complex hybrid mixtures of nicotinic acid, methane and lycopodium were prepared and studied their explosion behavior and flammability. Explosion tests were performed in explosion vessel of 20L. Exceptional behavior of hybrid complex with equal amount of nicotinic acid and lycopodium was observed and noticed that it was most reactive than other mixtures [37].
The iso nicotinic acid N-oxide complex of Mn(II) element was prepared and element analysis and also X-ray crystallography were used for characterization of complexes. Ions of Mn(II)in the complex to have coordination with 6-8 molecules of water, plus the coordination Number could be six with the Mn(II) ion. Spectras of FTIR spectra with the in the stove 4000-400 cm -1 were recorded for the free iso nicotinic chemical p N-oxide (INO) Complex. Cathodo luminescence spectra represented as (CL) from the Mn(II) complex happened to be analyzed. The luminescence information was recorded at 480 nm regarding the emission music group. The green luminescence) arises at (480 nm) from the Mn 2+ Change over 4T1 (4G)! 6A1 (6S). The item showed weak vibrionic design, small life time's fewer than 250 ls, and also indicated that Mn 2þ can be octahedrally coordinated, occupied 1360 websites with same distortions. The lifetime and intensity was heat range dependent with the signal, and the boundaries were shown for your emissions series at 480 nm [38].  (2), and also Co II (3); Hnic= nicotinic acid], happened to be prepared solv0 thermally and also characterized magnetically. X-ray diffraction analysis revealed that substances 1-3 were having frameworks of three-dimensions, which might be prepared through M 4 (μ 3 -OMe) 4 building like cubane obstructs and bridged as nic-anions. Measurements of variabletemperature permanent magnetic susceptibility indicated that they all showed antiferromagnetic conduct with variety of intra-cubane coupling constants. Complex 1 exhibited spin-frustration conduct, and was fixed that has a two-J model from the temperature range involving 2-300 K, giving J1 = -0. 95 and J2 = -2. Twenty three cm -1 Complexes 2 and also 3 were fixed with all the same model from the temperature range involving 30-300 K and also 40-300 K to provide the exchangeable coupling constants J 1 = -2. Forty-nine, J 2 = several. 84 cm-1 and also J 1 = -4. 16, J 2 = 5, Forty-four cm -1 , respectively. Two coordination polymers of azido manganese (II) were given by reactions of Mn ІІ ions along with azido ligands with the existence of nicotinic/isonicotinic acids, polymers were, [Mn 3 (L 1 ) 2 (N 3 ) 4 ] n 3NH 2 O (1) and also [Mn 2 (L 2 )(N 3 ) 3 ] n (2), in which L1 = nicotinate and also L2 = isonicotinate, along with variety of topological constructions. Complex 1 involves 2D azido-Mn(II) aircraft, which was even more coordinated by L 1 in order to create a 3D construction with un-parallel 3, 6-connected 4-nodal online topology, and complicated 2 presented the unprecedented 3, four, 6-connected 6-nodal three dimensional azido-Mn(II) structure with L 2 because of co-ligand. Magnetic susceptibility sizes showed prominent antiferromagnetic coupling current in 1 and 2 also. Complex 1 could be a spin-competitive system and entered right into transition of a low ferromagneticto-magnetic phase with the sensitive l temperature range regarding 6 K on account of spin canting. Complex 2 could be antiferromagnetic and revealed field-induced spin-flop habits [39]. From an energetically mind set, the regular ratio between matched up uni-dentate and bidentate bond lengths under the unity justifies, the geometry connected with the coordination polyhedral. In the structure of 1, the coordination polyhedron might be described its best as any distorted pentagonal bipyramid having a nitrogen from phenanthroline and also the molecule of water occupying the actual apical position. The shape for polyhedron 2 was near to a square-capped trigonal prism, the actual capping site getting occupied by the lake molecule. H-bonded bi-dimensional sheets piled up by p-p stacking from the partially interpenetrated aromatic moieties of adjoining layers designed the structure of the crystal [7].  .,2005).The geometry-based aromaticity indexes for benzoates metal, salicylates, nicotinates and derivatives of benzene were calculated. They studied the stabilizing metals effect on the system of p-electron s. The given and previous spectroscopic results were analyzed and statistically analyzed and their applications of the indexes were discussed. The highest degree of electronic charge distribution was in following elements: Al, Cr, Mg, Ni and Zn [8] It was given that an acetamide complex was synthesized which holds two terminal imidazole rings.   (3), besides small functionalized derivatives, continued our structural-activity studies by exploring with the amino thiophenol area ('northeastern region') in your original target construction azalanstat (1). Inside vitro, most with the complexes in this series were found to be inhibitors that were highly potent with the stress-induced isozyme HO-1 and the constitutive isozyme HO-2, demonstrating only optimum selectivity with regard to HO-1. Nevertheless, some of the complexes showed larger selectivity toward HO-1. None with the complexes having a larger appendage in the northeastern region were being inhibitors of CYP2E1, whereas a compound using relatively small substituent fluorine in this region did blocked CYP2E1; each of the complex tested showed very high inhibitory effectiveness towards CYP3A1/3A2 [46]. It was stated that complexes of Z-2-benzyltbio-4-hydroximinomethyl-l-p-methoxyphenyl imidazole (Z-OXLME) along with Co", Ni", Cui', Zn", Cd" and Hg" were synthesized and characterized simply by IR, W-vis-NIR reflectance, 'H and 13C NMR spectroscopic methods and magnetic and winter calculations. In all of the compounds the organic and natural complexes act as a chelates through N(3) imida and Noximea toms [48]. Barszcz et al. (1999) [49]  with N-Methyl imidazole. This coordination complex characterized by crystallographic and spectroscopic method. By applying xanthine-xanthine oxidase assay, SOD (superoxide dismutase activity) of the complex was determined [50].
Processes were explained for that preparation carboxylate complex of manganese that was tetra-nuclear with ligands produced from4-imidazoleacetic acid (imidacH) along with 4-imidazolecarboxylic acid (imidcarbH  (3); R=Ph (4) could be formed. The structure 2 of X-ray revealed that the anion containing an [Mn 4 (m 3 -O) 2 ] 8 core while using four atoms of Mn showed in a very 'butterfly' arrangement and also the atoms of O triply connecting each 'wing'. Peripheral ligation is furnished by seven bridging O 2 CPh-ligands along with two chelating imi organizations. All given data of characterization were in keeping with the same central for complexes 1, 3 along with 4, along with the buildings that differed only inside terminal ligation. 1H NMR spectroscopy of four complexes indicates that the structure was looked after in solution and a lot of the resonating structures have been given based on T1 measurements along with substitution and swap practical. Cyclic voltammetry showed the existence of the single quasi-reversible oxidation functions for complexes 1 along with 2 [51].  (2) had been prepared by hydrothermal method and seen as a IR, elemental research and XRD technique. Complex 1 crystallized in a chiral space classP212121 has a 2D network design. Complex 2 was really a 3D open composition with 1D station where 1D zigzag water chains tend to be residue by hydrogenbonding friendships and chiral space crystallization in class Cc. Both 1 as well as 2 showed a solid harmonic creation (SHG) response [52]. By using Schiff bases, compounds of Zn(II), Mn(II) and Fe(III) produced by amino based mercapto triazole. The magnetic, elemental and spectroscopic studies showed that metal complexes occupied an octahedral pattern (geometry). The Schiff bases along with their metal complexes explained fluorescent properties. An antibacterial scientific investigation of Schiff facets along their metallic compounds towards various bacteria (E.coli, S. aureus, Pseudomonas aeruginosa and B. subtilis) along with fungal (A. niger, and P. chrysogenum) species through slow inhibitory focus method showed that metal compounds own more of the healing antimicrobial phenomenon as compare to Schiff bases. Deoxy ribonuclease (DNA) cleavage plays an important role with Mn (II), Fe(III) and Zn(II) complexes in the concern biological system [53]. improvements in the activity can be further achieved by slight modifications in the substituents on the basic imidazole and nicotinic acid nucleus. Thus imidazole and nicotinic acid complexes of Cu(II) and Mn(II) offers better pharmacodynamic characteristics. Furthermore, some imidazole drugs, at high concentrations, could exert direct inhibitory effects on membranes, without interference with sterols and sterol esters. Various recent new drugs developments in imidazole and nicotinic acid complexes of Cu(II) and Mn(II) show better effect and less toxicity.