RELATIONSHIP BETWEEN MOLAR PREGNANCY AND THYROID FUNCTION IN KINGDOM OF SAUDI ARABIA

1. Consultanat OB/GYN, Obstetric and Gynecology Department, King Abdullah Medical Complex, Jeddah, Saudi Arabia. 2. Medical intern, Ibn Sina National College, KSA (postal address: Jeddah, Al-Thaghr neighborhood 22338). 3. Medical intern, King Abdulaziz University, KSA. 4. Medical intern, Ibn Sina National College, KSA. 5. Medical intern, Batterjee Medical College, KSA. 6. Medical intern, Umm al-Qura University, KSA. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History


27
it and worked to publish it although it is very old time and although this study is not inside Saudi Arabia, but this is unique and integrated as a start and start Good for this topic. On the other hand,I regret to say that there is no research on this subject within Saudi Arabia. maybe this is a good way for my research to begin good start to be considered a unique and the first in Saudi Arabia

Prevalence of gestational trophoblastic disease. A single institution experience the conclusion was:
The incidence of GTD has declined with the rapid socio-medical development of the KSA, and is now comparable to that of Europe. The optimal management of this disease depends on prompt diagnosis, correct stratification of the risk category and appropriate treatment using various modalities such as chemotherapy and surgery. (TY, 2003) It is strange that I find this only study on the prevalence of molar pregnancy in Saudi Arabia and I regret to say that a long time ago, but I am very happy that it is the first study to raise the subject and agree with this study in an integrated An old.

Research Aim:
To determine the relationship between molar pregnancy and thyroid function in kingdom of Saudi Arabia.
Objectives:-1. To discover the most affected age by molar pregnancy. 2. To determine the relationship between delayed first pregnancy and the incidence of molar pregnancy. 3. Percentage of molar pregnancy to thyroid dysfunction.

Methodology:-Study design:
This is an analytical cross-sectional study.

Study Setting and period:
This is an analytical cross-sectional study conducted in kingdom of saudia Arabia (from females IP and OP), from 1/4/2019 till 19/10/2019.

Study population and sampling:
Study participants: Inclusion criteria: females married or who were previously married. Exclusion criteria; males and Virgin girls who have never been married.

Sampling Method:-
The study will be carried out by questionnaire.

Sampling size:
Sample size was calculated using OpenEpi for sample size calculation for cross sectional studies, hypothesizing the true answers Accordingly, 431 participants were gathered from the hospital patients. score of prevalence of who have suffered from molar pregnancy 11.60%, prevalence of who suffering from health problems in the thyroid function 16.24%.
According to the prevalence study, the results indicated that 14.62% of the respondents have hypothyroidism problem.

Measurements:-
Explanatory variables: 1. Sociodemographic characteristics: age. 2. Disease-related information: molar pregnancy, number of molar pregnancy,thyroid function, time of thyroid function problem, type of thyroid function problem.

Outcome measures:
The outcome measure is by counting the ratio of the number of patients have suffered from molar pregnancy this will be measured using: By determining the extent of the disease in addition to the associated with health problems in the thyroid function.
Prevalence study: will be carried to test the questionnaire if easily understood and the response of the participants. Data from the crosssectional study will be used to calculate the sample size.

Data Management and Analysis plan:
Data will be entered and analyzed using SPSS version 17.0 Descriptive statistics will be performed and categorical data will be displayed as frequencies and percentages while measures of central tendencies and measures and dispersion will be used to summarize continuous variables. Univariate and multivariate analysis will be performed to investigate association between exposure factors and associated disease. statistical significance is set at a P value of 0.05 or less.

Statistical analysis:
Data were entered and analyzed using Statistical Package for the Social Sciences (SPSS) version 17. Descriptive statistics were displayed as frequencies and percentages for categorical variables. Measures of central tendencies (the median), and measures and dispersion (minimummaximum) were used to summarize continuous variables, as the continuous variables were not normally distributed when tested by Shapiro-Wilk test. Univariate analysis was performed to investigate the association between the exposure factors with the outcome on the one hand, this was performed using Chi-squared test and Mann-Whitney test. Multivariate analysis to investigate factors independently was performed using binary logistic regression. P value was set at a significance level of < 0.05.

Results:-
In this study, the aim was to determine the relationship between molar pregnancy and thyroid function in kingdom of Saudi Arabia, 431 patients' participants, were consecutively recruited from in patients' clinics, during a period from 1/4/2019 to 19/10/2019 According to disease 88.40% did not suffer from molar pregnancy, 16.24% suffering from health problems in the thyroid function .      34

Discussion:-
This study was based on a number of 431 participants, from this study as the number of females have suffered from molar pregnancy is 50, 63 of them have kidney disease, of them having health problems in the thyroid function.
The current study showed statistically significant (P value is 0.01) and (P value is 0.05), Through the questionnaire it was found that there is a strong correlation between cluster pregnancy and thyroid function..

Conclusion:-
1. The results of the study showed positive results in terms of decreased incidence of molar pregnancy.
2. The results demonstrate that there is a strong correlation between cluster pregnancy and thyroid function. 3. The results showed that most of the respondents do not suffer from any health problems in the thyroid function which is a good thing. 4. The results demonstrated that there is a strong correlation between the type of problem in the thyroid gland and the cluster pregnancy. 5. Also , there is a strong correlation between the type of problem in the thyroid gland and the number of the pregnancy when the woman is pregnant with a molar pregnancy.

Recommendation:-
we recommend setting up health education programs about the molar pregnancy and thyroid diseases , this health problem must be presented broadly and beneficially and, in a way, that everyone understands, as most deal with the thyroid disease by ignoring and not being important, work should be done on health conferences and medical discussions on that.