DESIGN OF MEMS-BASED BIOSENSOR TO ESTIMATE THE BIOMECHANICAL PROPERTY OF COLORECTAL CANCER CELL

Recently the evolving approach in medical applications, the biomechanical properties of single cells have been developed, as they are closely related to cell biological processes and eventually to human health conditions. The biomechanical properties can be used for early cancer diagnosis as biomarkers because cancer cells have moderately less Young's modulus. We measured the stiffness of individual benign (CCD-18), non-invasive malignant (HT-29), and highly-invasive malignant (SW480) colorectal cancer cells using the MEMS sensors. The elastic modulus of three colon cell lines could be extracted, where the cells were SW480~1.12 kPa, HT-29 cells were ~ 1.31 kPa and CCD-18 cells were ~2.34 kPa.