16Jun 2021

CORRELATION BETWEEN FATTY BINDING PROTEIN 1 (FABP1) AND DIABETES TYPE 2 (T2DM)

  • Misr University for Science and Technology, Egypt.
  • Division of Biochemistry, Chemistry Department, Faculty of Science, Fayoum, Egypt.
  • Internal Medicine Department, Faculty of Medicine, Misr University for Science and Technology, Egypt.
  • Clinical and Chemical Pathology Department, National Institute of Diabetes and Endocrinology, Egypt.
  • Biochemistry Department, National Hepatology & Tropical Medicine Research Institute. Clinical and Chemical Pathology Department, El Sahel Teaching Hospital.
  • Clinical and Chemical Pathology Department, El Sahel Teaching Hospital.
  • Internal Medicine, National Institute of Diabetes and Endocrinology, Egypt.
  • Nutrition and Food Science, National Institute of Diabetes and Endocrinology.
  • Hepatology Department, Ahmed Maher Teaching Hospital, Cairo, Egypt.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • Cite This Article as
  • Corresponding Author

Background: Diabetes mellitus is best described as a condition that is characterized by postprandial hyperglycemia that has two types; diabetes type 1 and type 2. Many patients with type 2 diabetes can be asymptomatic. There are many novel biomarkers for the detection of diabetes type 2, such as FABP1, which is investigated as a marker to detect patients with diabetes type 2.

Aim: The aim of the study was to investigate FABP1 in Patients with diabetes type 2 and to find the correlations between FABP1 and fasting insulin in those patients. 

Methods: Samples were collected from 99 diabetic patients

and 85 samples of healthy participants as the control group. All participants were subjected to liver enzymes (ALT and AST) lipid profile (triglycerides, HDL, LDL, and cholesterol), T-billirbun, Albumin, Alp, AFP, BMI, S-creatinine, Hb, Fatty acids, F. Insulin, CA19.9, HbA1c, and Fbs that were done by an autoanalyzer. The serum level of fatty acid-binding protein 1 was measured by SunRed human FABP1 Elisa kits.

Results: Data was represented as mean ± standard deviation or median with statistically significant values of ALT, AST, ALP, PT, and INR (at P< 0.05). Findings revealed a significant positive correlation between our marker FABP1 and TG, cholesterol, LDL, Fasting insulin, and CA19.9,

Conclusion: FABP1 can be used as a novel marker to detect patients with diabetes type 2.


[Sofia Ashraf Abd Elhady, Asmaa Mohamed Mansour, Hassan Shalby, Naglaa Fawazy, Yasser Sakr, Abeer A. Barakat, Hala H. Eldeeb, Ahmed Sobhy Adaroas, Wafaa Salah, Amina S. Soliman and Mohamed Ramdan Ezz AL Arab (2021); CORRELATION BETWEEN FATTY BINDING PROTEIN 1 (FABP1) AND DIABETES TYPE 2 (T2DM) Int. J. of Adv. Res. 9 (Jun). 645-650] (ISSN 2320-5407). www.journalijar.com


Sofia Ashraf Abd-Elhadym
Misr University for science and technology, Egypt.

DOI:


Article DOI: 10.21474/IJAR01/13058      
DOI URL: http://dx.doi.org/10.21474/IJAR01/13058