A COMPARATIVE ANALYSIS OF SERUM MALONDIALDEHYDE LEVELS AS A MARKER OF OXIDATIVE STRESS IN ACUTE MYOCARDIAL INFARCTION CASES WITH AND WITHOUT T2DM.
- 1. Department of Medicine, Princess Esra Hospital (PEH), Deccan College of Medical Sciences (DCMS), Hyderabad, India.
- 2. Department of Cardiology, Princess Esra Hospital, DCMS, Hyderabad, India.
- 3. Prof and HOD, Salar-E-millat Research Centre for Cellular and Molecular Medicine, PEH, DCMS, Hyderabad, India.
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Oxidative stress is considered as one of the important mechanism in the causation of type 2 diabetes (T2DM) as well as cardiovascular diseases. Quantification of serum malondialdehyde (MDA) is generally employed as reliable marker of assessment of oxidative stress. The objective of the present study was to estimate serum MDA levels in acute myocardial infarction cases with and without T2DM. A total of 60 AMI patients were studied, including 30 cases of AMI with T2DM and an equal number of cases of AMI without T2DM. Mean serum levels of MDA were 543.17± 56.97 and 423.50 ± 51.12 nmol/dL respectively in cases of AMI with T2DM and those without T2DM (p<0.05). Significantly elevated levels of serum MDA were observed in T2DM cases with AMI than those without T2DM. Significance of the results has been discussed in terms of age at onset as well as severity of AMI.
[M.A.Raheem, M.Siraj, Rajashekar Reddy, Syed Azhar Ali, Priyanka T N and M Ishaq. (2016); A COMPARATIVE ANALYSIS OF SERUM MALONDIALDEHYDE LEVELS AS A MARKER OF OXIDATIVE STRESS IN ACUTE MYOCARDIAL INFARCTION CASES WITH AND WITHOUT T2DM. Int. J. of Adv. Res. 4 (Jun). 1270-1272] (ISSN 2320-5407). www.journalijar.com
