NEPHROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF PETROSLINUM CRISPUMS LEAVES AGAINST RIFAMPIN INDUCED NEPHROTOXICITY IN RATS.
- Department of Biochemistry, School of Medical Laboratories Sharg Alneel college. Khartoum Sudan.
- Department of Biochemistry, Faculty of Science and technology, Alneelain University, Khartoum, Sudan.
- Department of Biochemistry, Veterinary Research Institute, Animal Resources Research Corporation. P.O.Box. 8067 Alamarat Khartoum Sudan.
- Abstract
- Cite This Article as
- Corresponding Author
The study was conducted for the renal protective activity of methanolic extract of, Petroslinum crispum leaves against renal toxicity induced by rifampin injection in rats. This plant is used in traditional medicine for the treatment of renal failure, inflammation of kidney and other disease. The renal toxicity was produced by administration of rifampin at dose rate70 mg/kg I/p for 28 days. The plant extract was given by simultaneous oral administration of methanolic extract of Petroslinum crispum leaves at a dose rate of 300 and 600mg/kg for 28 days. It was found that the induced toxicity was inhibited by decreased level of serum urea, creatinin, sodium (Na) and potassium (K). Histopathological examination revealed protection of the kidney from the marked necrosis of renal tubules that induced by rifampin.
[Esraa Ramadan, Tarig. H. A. Bilal, Idris, O. F and Samia H. Abdelrahman. (2016); NEPHROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF PETROSLINUM CRISPUMS LEAVES AGAINST RIFAMPIN INDUCED NEPHROTOXICITY IN RATS. Int. J. of Adv. Res. 4 (Nov). 1482-1489] (ISSN 2320-5407). www.journalijar.com
