STUDY OF ALTERNATIVE WILMS TUMOR GENE EXPRESSION IN ACUTE MYELOID LEUKEMIA.
Magdy Mamdouh El Bordiny
, Ashraf Hussien Al-Ghandour
, Reham Abdel Haleem Abo Elwafa
and Omneya Mohamed Kamal Fayed.
- Professor in Clinical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
- Professor in Internal Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
- Lecturer in Clinical Pathology Department, Faculty of medicine, Alexandria University, Alexandria, Egypt.
- Specialist in, Alexandria University Hospitals, Alexandria, Egypt.
- Abstract
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Background:Wilms tumor 1 (WT1) is over-expressed in numerous cancers with respect to normal cells, and haseither a tumor suppressor or oncogenic role depending on cellular context. This gene is associated with numerous alternatively spliced transcripts, which initiate from two different unique first exons within the WT1 and the alternative (A)WT1promoter intervals. Objective: We studied the AWT1 gene expression profile and its relation with other clinicopathological features in AML. Methods: The level of AWT1 expression was assessed in 40 newly diagnosed AML patients and 40 healthy subjects as a control group usingRQ- PCR. Results:AWT1 expression level was significantly higher in the AML patients in comparisonto the control group (p<0.01).
[Magdy Mamdouh El Bordiny, Ashraf Hussien Al-Ghandour, Reham Abdel Haleem Abo Elwafa and Omneya Mohamed Kamal Fayed. (2016); STUDY OF ALTERNATIVE WILMS TUMOR GENE EXPRESSION IN ACUTE MYELOID LEUKEMIA. Int. J. of Adv. Res. 4 (Nov). 1049-1053] (ISSN 2320-5407). www.journalijar.com
