20Jan 2017

QUANTITATIVE DETERMINATION OF RUBIADIN IN DIFFERENT ACCESSIONS OF RUBIA CORDIFOLIA LINN. BY ISOCRATIC RP-HPLC

  • Department of Biotechnology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi-110062, India. Department of Botany, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi-110062, India. Department of Botany, Aligarh Muslim University, Aligarh-202001, India.
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Rubia cordifolia L. (common name-Indian Madder, Majith, Manjistha) from the family Rubiaceae is commonly known as is widely dispersed throughout the lower hills of India. The plant is famous drug in the Ayurvedic treatments. Extracts of this plant have shown many important medicinal properties.In this study, we quantified the amount of rubiadin in both roots and aerial part of the plant. Theamount of the active principle is affected by the geographical areas. So, we also compared the amount of rubiadin in different accessions of the R. cordifolia Linn. that have been collected from different geographical areas of the India.

  1. Banyal, P., Kuzovkina, I., Kursinszki, L., Szoke, E. (2006). HPLC Analysis of Alizarin and Purpurinproduced by Rubia tinctorum Hairy Root Cultures. Chromatographia, 63: S111-S114.
  2. Comini, L.R., Montoya, S.C., P?ez, P.L., Arg?ello, G.A., Albesa, I., Cabrera, J.L. (2011). Antibacterial activity of anthraquinone derivatives from Heterophyllaeapustulata (Rubiaceae). Journal of Photochemistry and Photobiology. B, Biology, 102: 108-114.
  3. Deoda, R.S., Kumar, D., Bhujbal, S.S. (2011). Gastro protective Effect of Rubia cordifolia on Aspirin Plus Pylorus-Ligated Ulcer. Evidence-Based Complementary and Alternative Medicine. Article ID 541624, 5 pages.
  4. Gilani, A.H., Janbaz, K.H. (1995). Effect of Rubia cordifolia extract on acetaminophen and CCl4-induced hepatotoxicity. Phytother Res.,9: 372-375.
  5. Khodke, A.S., Potale, L.V., Patole, S.M., Damle, M.C. (2010). A Validated Isocratic RP-HPLC Method determination for Rubiadin in the roots of Rubia cordifolia Int.J. Chem. Tech. Res., 2: 1955-1958.
  6. Mythili, K., Gayatri, S., Koya, R.T., Chitra, K., C.Uma, M.R. (2011). Development and validation of RP-HPLC method for the estimation of Strontium ranelate in sachet. IntenationalJournal of Pharma& Biosciences, 2: 258-263.
  7. Radha, R.K., Shereena, S.R., Divya, K., Krishnan, P.N., Seeni, S. (2011). In vitro Propagation of Rubia cordifolia , A medicinal plant of the western Ghats. International Journal of Botany, 7: 90-96.
  8. Rao, G.M., Rao, C.V., Pushpangadan, P., Shirwaikar, A. (2006). Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Journal of Ethnopharmacology, 103: 484-490.
  9. Shekhar, T.C., Bahuguna, Y.M., Vijender, S. (2010). Anti-Inflammatory activity of ethanolic stem extracts of Rubia cordifolia in Rats. IJRAP, 1: 126-130.
  10. Tripathi, Y.B., Sharma, M., Manickam, M. (1997). Rubiadin, a new antioxidant from Rubia cordifolia.Indian Journal of Biochemistry & Biophysics,34: 302-306.

[Mohd Mughees, Shipra Rani Jha, Shabnam Akhtar, Javed Ahmad and Altaf Ahmad. (2017); QUANTITATIVE DETERMINATION OF RUBIADIN IN DIFFERENT ACCESSIONS OF RUBIA CORDIFOLIA LINN. BY ISOCRATIC RP-HPLC Int. J. of Adv. Res. 5 (Jan). 181-186] (ISSN 2320-5407). www.journalijar.com

Prof. Altaf Ahmad
Department of Botany, Aligarh Muslim University, Aligarh -202001.

DOI:

Article DOI: 10.21474/IJAR01/2735      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2735

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