Phytochemical screening and Antimicrobial activity of Euphorbia linearifolia var.nallamalayana J.L.Ellis from the Nucleus of Eastern Ghats.
- Department of Botany and Microbiology, Nagarjuna University, Guntur, Andhra Pradesh, India. Department of Botany and Microbiology, Acharya Nagarjuna University Guntur, Andhra Pradesh, India.
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The current study was focused to investigate the phytochemical analysis, antibacterial and antifungal activity of plant extract of Euphorbia nallamalayana against different pathogens. Four solvent extracts were evaluated for antimicrobial activity using well diffusion method and MIC determination on different micro organisms. The shade dried plant material was subjected to different solvents for phytochemical screening. The antibacterial activity was done using well diffusion method against eight potentially pathogenic microorganisms Aspergillus niger,Aspergillus flavus,Candida albicans, Saccharomyces cerevisiae , Escherchia coli , Staphylococcus aureus, Bacillus subtilus and Pseudomonas aeruginosa. Phytochemical screening was done using standard qualitative methods which revealed the presence of Tannins, Saponins, Steroids, coumarins, Flavones, Flavanones, Phenols, Quinones and Carbohydrates. There was no antifungal activity with Asperigillus flavus,Candida albicans and Saccharomyces cerevisiae.The findings of this study indicate that the plant extract of Euphorbia nallamalayana showed significant antibacterial activity against both gram positive and gram negative organisms. We also found the antifungal activity against Aspergillus niger. However, further studies on isolation characterization of plant extract responsible for antibacterial activity is necessary to elucidate their mechanism of action and it would give comprehensive evidence of bioactive potential of medicinal plants at cellular and molecular levels. Euphorbia nallamalayana has a strong antimicrobial potential, which justifies its use in folk medicine for treatment of infectious diseases. Since this species is poorly investigated, further refined studies on it pure secondary metabolites are needed and very important, in the perspective to identify new antimicrobial molecules from this endemic plant.
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[D.Nirmala Grace and Z.Vishnu Vardhan. (2017); Phytochemical screening and Antimicrobial activity of Euphorbia linearifolia var.nallamalayana J.L.Ellis from the Nucleus of Eastern Ghats. Int. J. of Adv. Res. 5 (Jan). 326-333] (ISSN 2320-5407). www.journalijar.com
ACHARYA NAGARJUNA UNIVERSITY
Article DOI: 10.21474/IJAR01/2750 DOI URL: http://dx.doi.org/10.21474/IJAR01/2750
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