20Jan 2017

METASTATIC OVARIAN TUMOR DISCOVERED ACCIDENTALLY DURING CESAREAN SECTION IN A 34-YEAR-OLD WOMAN: A CASE REPORT.

  • Associate Professor of Pathology;Department of Pathology, Faculty of Medicine, Tanta University, Egypt.
  • Department of Pathology, Faculty of Medicine, Umm Al-Qura University, KSA.
  • Intern; Faculty of Medicine, Umm Al-Qura University, KSA.
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Krukenberg tumor is a rare metastatic ovarian carcinoma usually occur in female between 30-40-year-old and rarely seen after menopause. Stomach is the most common primary site. Histopathological features of krukenberg tumors appears as diffuse stromal proliferation, mucus-production, and numerous signet-cells and these tumors spread mostly by lymphatic route. Treatment and prognostic factors are not well established. This study describes a 34 year old female with a unilateral ovarian mass discovered accidentally during cesarean section delivery and it was misdiagnosed as luteoma of pregnancy, but histopathological examination showed a diffuse infiltration of the ovary and omentum by malignant cells, some of which have signet ring morphology. These findings were not correlated with luteoma of pregnancy or any other types of primary ovarian tumors like primary surface epithelial tumor, sex cord stromal tumor or germ cell tumor. A panel of immunohistochemicalmarkers were ordered and the results were as follow: (negative CK7, AFP, and alpha inhibin, and positive EMA, CK20 and CDX-2). these findingswere diagnostic for metastatic adenocarcinoma either from the stomach or pancreas (krukenberg tumor). Two weeks later, the patient was evaluated and a large gastric tumor was found in her stomach and she underwent gastrectomy.


  1. Chen V.W., Ruiz B., Killeen J.L., et al., Pathology and classification of ovarian tumors. CNCR Cancer, 2003. 97(S10): p. 2631-2642.
  2. Nanda, A., U.A. Gokhale, and G.R. Pillai, Bilateral pregnancy luteoma: A case report. Oman Med. J. Oman Medical Journal, 2014. 29(5): p. 371-372.
  3. Fang WU, Xiaoaizhao, Baibing MI et al., Clinical characteristics and prognostic analysis of Krukenberg tumor. mol clin onc Molecular and Clinical Oncology, 2015.
  4. Rawasia W.F., Chaddha U., El-Kersh K., et al.,Dyspnoea and the ovaries: a rare presentation of Krukenberg tumour. BMJ case reports, 2013. 2013.
  5. Umakanthan, S., M.M. Bukelo, and K. Hardik, A 36-year-old female with Krukenberg tumor from a colonic carcinoma. Journal of cancer research and therapeutics, 2015. 11(4).
  6. Sahin S., Karatas F., Hacioglu B., et al.,Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature. Journal of cancer research and therapeutics, 2015. 11(4).
  7. AL-AGHA OM, & NICASTRI AD. (2006). An in-depth look at Krukenberg tumor: an overview. Archives of Pathology & LaboratoryMedicine. 130, 1725-30.
  8. Shiono S., Saito T., Fujii H., et al., A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary. 2013, e-Century Publishing Corporation.
  9. Goyal S, Bhankar H, Tyagi N., et al., Incidentally diagnosed Krukenberg tumor in pregnancy: A rare presentation with dismal outcome. Clinical Cancer Investigation Journal, 2016;5(2):196.
  10. Kumar M., Kumar A., Maroules M., et al.,Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic factors and treatment of krukenberg tumor. Annals of translational medicine, 2016. 4(4).
  11. Co P.V., Gupta A., Attar B.M., et al.Gastric cancer presenting as a krukenberg tumor at 22 weeks gestation. J. Gastric Cancer Journal of Gastric Cancer, 2014. 14(4): p. 275-278.

[Ghada Esheba, Wafa'a Al-Harbi, GhufranKheshaifaty2,3, Kholoud Al-Harbi, Ala'a Al-Orabi and Moayad Turkistani. (2017); METASTATIC OVARIAN TUMOR DISCOVERED ACCIDENTALLY DURING CESAREAN SECTION IN A 34-YEAR-OLD WOMAN: A CASE REPORT. Int. J. of Adv. Res. 5 (Jan). 1233-1238] (ISSN 2320-5407). www.journalijar.com


Wafaa Alharbi
Intern; Faculty of Medicine, Umm Al-Qura University, KSA.

DOI:


Article DOI: 10.21474/IJAR01/2876      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2876