18Feb 2017

STUDY OF SERUM CALCIUM AND CREATININE LEVELS IN PREECLAMPTIC WOMEN BELOW 35 YEARS IN A TERTIARY CARE CENTRE IN SOUTHERN ASSAM , INDIA.

  • Department of Biochemistry,Silchar Medical College and Hospital,Silchar (Assam), India.
  • Professor and HOD, Department of Biochemistry, Silchar Medical College and Hospital, Silchar (Assam), India.
  • Associate professor,Department of Obstetrics & Gynaecology, Silchar Medical College and Hospital,Silchar (Assam), India.
  • Department of Biochemistry,Silchar Medical College and Hospital,Silchar (Assam), India.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Pre-eclampsia,a hypertensive multisystem disorder is one of the major causes of maternal morbidity and mortality. The exact aetiology is still unknown, though numerous hypotheses have been put forward. Studies have found that low serum calcium level may be associated with development of pre-eclampsia. The aim of this study was to find the association between serum calcium level and pre-eclampsia by comparing the serum calcium levels in pre-eclamptic women with that of normal pregnant ladies. Our findings in this study indicate that pre-eclamptic women had a significantly lower serum calcium level than normal pregnant women (p<0.01) and creatinine level was found to be higher in preeclamptics. (p<0.01) This study concludes that low serum calcium level may be a causal factor for the development of pre-eclampsia. So, intake of mineral supplements like calcium may reduce the incidence of pre-eclampsia.


  1. Solomon CG and Seely EW. Preeclampsia. Searching for the cause. New Eng J Med. 2004; 350: 641 ? 2.
  2. Sukonpan K, Phupong V. Serum calcium and serum magnesium in normal and pre-eclamptic pregnancy. Arch Gynecol Obstet. 2005; 273: 12-16.
  3. Chesley LC.Hypertensive disorders in pregnancy.?New York, NY: Appleton-Century- Crofts; 1978.
  4. Evans KN et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biology of Reproduction. 2006; 75:816?822.
  5. Walker JJ. Pre-eclampsia. Lancet 2000; 356: 1260-5.
  6. Bringman J, Gibbs C, Ahokas R. Differences in serum calcium and magnesium between gravidas with severe preeclampsia and normotensive controls. Am J Obstet Gynaecol. 2006; 195:148.
  7. Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn K H, Kosch M. Membrane, intracellular and plasma magnesium and calcium concentrations in pre-eclampsia. Am J Hypertens 2000; 13: 765-9.
  8. Ray J, Vasishta K, Kaur S, Majumdar S, Sawhney H. Calcium metabolism in pre-eclampsia. Int J Gynaecol Obstet 1999; 66: 245-50.
  9. Manjareeka M,Sitikantha N.Elevated levels of serum uric acid,creatinine or urea in preeclamptic women.Int J Med Sci Public Heal 2013;2(1):43-7
  10. Jeyabalan A,Conrad KP.Renal function during normal pregnancy and preeclampsia.Front Biosci 2007;12:2425-37.
  11. Malas NO, Sheridan ZM. Does serum calcium in pre-eclampsia and normal pregnancy differ? Saudi Med J 2001 Oct; 22(10): 868-71.
  12. Belizan JM, Villar J. The relationship between calcium intake and oedema, proteinuria and hypertension gestosis: a hypothesis.Am J Clin Nutr.?1980;33:2202?10.
  13. Hofmeyr GJ, Lawrie TA, Atallah ?N, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. The Cochrane Library. 2010 Jan 1.
  14. Kanagal DV, Rajesh A, Rao K, Devi UH, Shetty H, Kumari S, Shetty PK. Levels of serum calcium and magnesium in pre-eclamptic and normal pregnancy: A study from Coastal India. J Clin Diagn Res. 2014 Jul 1;8(7):1-4.
  15. Akhtar S, Begum S, Ferdousi S. Calcium and Zinc Deficiency in Pre-eclamptic Women.J Bangldesh Soc Physiol.?2011;6(2):94?9.
  16. Chaurasia PP, Jadav PA, Jasani JH. Changed in Serum Calcium and Serum Magnesium Level In Pre-eclamptic VS Normal Pregnancy.?2012;3(6):511?3.
  17. PadmaY,AparnaVB,Kalpana B,Ritika V,Sudhakar PR.Renal markers in normal and hypertensive disorders of pregnancy in Indian women:a pilot study.Int J Reprod Contracept Obs Gynecol 2013;2:514-20.
  18. P. Conrad, L. W. Gaber, and M. D. Lindheimer, ?The kidney in normal pregnancy and preeclampsia,? in?Chesley's Hypertensive Disorders in Pregnancy, M. D. Lindheimer, F. G. Cunningham, and J. M. Roberts, Eds., pp. 301?340, Elsevier, Amsterdam, The Netherlands, 3rd edition, 2009.
  19. Manjareeka M, Nanda S. Elevated levels of serum uric acid, creatinine or urea in preeclamptic women. Int J Med Sci Public Health. (2013), [cited August 23, 2016]; 2(1): 43-47.
  20. Salako BL, Odukogbe AT, Olayemi O, Adedapo KS, Aimakhu CO, Alu FE, Ola B. Serum albumin, creatinine, uric acid and hypertensive disorders of pregnancy. East African medical journal. 2003 Aug 1;80(8):424-8
  21. Hayashi T. and Philadelphia P. Uric acid and endogenous creatinine clearance studies in normal pregnancy and toxaemias of pregnancy. J. Obstet. Gynaecol. 1956;71:859-870

[Aparajeeta Bora, Mauchumi Saikia Pathak, Arun Paul Choudhury and Safiq Ahmed. (2017); STUDY OF SERUM CALCIUM AND CREATININE LEVELS IN PREECLAMPTIC WOMEN BELOW 35 YEARS IN A TERTIARY CARE CENTRE IN SOUTHERN ASSAM , INDIA. Int. J. of Adv. Res. 5 (Feb). 898-903] (ISSN 2320-5407). www.journalijar.com


APARAJEETA BORA
DEPARTMENT OF BIOCHEMISTRY,SILCHAR MEDICAL COLLEGE AND HOSPITAL,SILCHAR(ASSAM) INDIA

DOI:


Article DOI: 10.21474/IJAR01/3231      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3231