18Sep 2017

ROLE OF INTERFERON-Γ AND INTERLUKIN-10 ON THE PATHOGENESIS OF ASTHMA PHENOTYPES IN SAUDI PATIENTS.

  • Ministry of Health, Administration of Laboratory and Blood bank, Riyadh, 21911, Saudi Arabia.
  • College of Applied Medical Sciences, King Saud University, Riyadh, 10219, Saudi Arabia.
  • College of Applied Medical Sciences, Taif University, Taif, 21974, Saudi Arabia.
  • Ministry of Health, King Saud Medical City, Riyadh, 331771, Saudi Arabia.
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Asthma is a chronic disorder of the airways that is characterized by reversible airflow obstruction, inflammation, and persistent airway hyperactivity. Aim of this study: was to assess the potential value of serum IFN-γ and IL-10 as biomarkers in the pathogenesis of atopic and non-atopic asthma in Saudi patients, by measurement of serum IFN- γ and IL-10 levels in atopic asthmatic and allergic patients as well as healthy volunteers. Method: A total of 160 blood samples were assessed in this study, out of them 120 blood samples were collected from asthmatic patients at different ages and gender as well as case severity, while 40 blood samples were collected from control volunteers. These samples were collected in King Saud Medical City, kingdom of Saudi Arabia, Riyadh. Results: the study data showed that levels of IL-10 were significantly higher in asthmatic patients, while levels of INF-γ showed marked decrease in asthmatic patients compared to the study control volunteers. This indicates that there is immunological imbalance between Th1 and Th2 cytokines in asthmatic patients.

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[*Al-Shehri AS, Al-Shehri SS, Al-Hamidi AH, Dalati TA, Alhazmi AS and Eid GE. (2017); ROLE OF INTERFERON-Γ AND INTERLUKIN-10 ON THE PATHOGENESIS OF ASTHMA PHENOTYPES IN SAUDI PATIENTS. Int. J. of Adv. Res. 5 (Sep). 506-511] (ISSN 2320-5407). www.journalijar.com

Dr Saad Al-Shehri
College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia

DOI:

Article DOI: 10.21474/IJAR01/5353      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5353

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