The possible role of human parvovirus B19, Nuclear factor- kappa B p65 and interleukin- 6 in thyroid tumors

The present study was designed to detect parvovirus B19, NF-?B p65 and IL-6 by immunohistochemical technique and to investigate the correlation between them in Iraqi patients with different types of malignant and benign thyroid tumors. A total number of (94) formalin-fixed paraffine-embeded thyroid tumors tissue collected from archives department of histopathology laboratories during the period from July 2013 till November 2013. Tissue blocks were divided into three groups. First one included (53) tissue block of malignancy thyroid whereas the second group included (41) tissue blocks of benign thyroid tumors and the third group included (21) tissue blocks which were selected from the same benign cases which have normal tissue. By using immunohistochemistry, B19 virus was detected in (66%) of malignant cases compared to (48.8%) in benign tumors. NF-?B p65 was positively expressed in all cases of malignant tumors and (97.6%) of benign tumors compared with (23.8%) normal tissue, p?0.001. IL-6 expression was higher in benign than that in malignant tumors but the difference was not significant (90.2% versus 81.1%, p=0.22), while it was significantly higher in benign and malignant tumors compared with normal tissue (52.4%, p=0.01 and p=003) respectively. In conclusion the results suggest the possible noxious role of B19 virus in these tumors. The high rate of expression of NF-?B p65 in tissue of thyroid tumors may indicates it’s important role in cancer signaling pathways and finally IL-6 could play a role in immunological microenvironment of thyroid tumors regardless of presence or absence of parvovirus B19.