28Feb 2017

ASSOCIATION OF D-DIMER IN TYPE 2 DIABETES MELLITUS.

  • B-401,Faculty Quarter,Gmers Medical College Campus,Valsad.
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Context: Diabetes mellitus is a leading cause of vascular morbidity. Etiology of diabetic vascular complications is multifactorial. Alteration of blood coagulation and fibrinolysis along with poor glycaemic control in diabetes has also been implicated in the development of diabetic vascular complications. Plasma level of D-Dimer reflects the amount of lysed cross-linked fibrin and hence is an accepted marker of hypercoagulability. Aim: The aim of this study is to evaluate the clinical significance of plasma D-dimer in type 2 Diabetes Mellitus. Settings and Design: This study is a cross sectional study. Methods and Material: A total of 90 patients were selected based on clinical status and divided into 3 groups: 30 patients of newly detected type 2 DM, 30 patients having diabetic nephropathy and 30 patients of DM with coronary artery disease. Plasma Ddimer was measured using Second-generation latex agglutination (immunoturbidimetric) method in Cobas Integra 400 plus. The lipid profile and HbA1c were also measured. Statistical analysis used: Statistical analysis was performed by one way ANOVA, scheffe post hoc test and independent t- test. Results: Patients with diabetic nephropathy had significantly higher plasma D-dimer levels (2.48±1.28?g/mL) than patients without complications (0.28±0.12 ?g/mL) (p < 0.0001). There were significantly higher plasma D-dimer levels in patients with coronaryartery disease (2.05±1.06 ?g/mL) than patients without complications (0.28±0.12 ?g/mL) (p < 0.0001). And there is no significant different in lipid profile in DM with or withoutcoronary artery diseases. Conclusions: Our data suggest that in DM patients presenting with coronary artery diseases without dyslipidemias, the D-Dimer can serve as a novel marker for prediction of the risk of coronary artery diseases and higher level of D-Dimer in diabetic nephropathy patients suggest that increased thrombogenic state may be related to increased susceptibility of vascular disease in these patients.

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[Dhara Kanani, Vaidehipatel, kiranchauhan and N. Haridas. (2017); ASSOCIATION OF D-DIMER IN TYPE 2 DIABETES MELLITUS. Int. J. of Adv. Res. 5 (Feb). 2139-2145] (ISSN 2320-5407). www.journalijar.com

Dr.Dhara Kanani
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Article DOI: 10.21474/IJAR01/3387      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3387

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