28May 2017

IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES.

  • Young Researchers and Elite Club, Urmia Branch, Islamic Azad University, Urmia, Iran.
  • Faculty of science, Urmia Branch, Islamic Azad University, Urmia, Iran.
  • Department of laboratory Sciences, School of Paramedicine, Tabriz Universityof Medical Sciences, Tabriz, Iran.
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Background: The need of new antimicrobial agents is justified because more microorganisms are being resistance to the currently available antibacterial drugs and this is bringing alarming threat to public health and causing growing concern among people across the globe. 1,3,4-Oxadiazole have shown a wide spectrum of antimicrobial activity. Some of the marketed drugs also possessed this heterocyclicmoiety. Objectives: We have previously synthesized new series of (5-aryl-1,3,4-oxadiazol-2-yl)(pyridin-2-yl)methanol derivatives (4a-4d) in fairly high yields. Here, we evaluated the antimicrobial activity of these derivatives against the following microorganisms: Staphylococcus epidermidis ATCC14990, Bacillus cereus PTCC 1015 , Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Candida tropicalis PTCC 5028and Candida albicansATCC10239. Materials and Method: The broth macrodilutionand well agar diffusion methods were used for determination of inhibition zoom(IZ) and minimum inhibitory concentration (MIC) during preliminary evaluation of antimicrobial activity. Results: All of the synthesized compounds exhibited promising antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Conclusions: In this study, data suggest that compound (4a-4d) is a potent antibacterial compound with excellent MICs and acceptable selectivity index against Staphylococcal infections.

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[Maryam Kouhkan, Fatemeh Karimi, Ali Souldozi and Jalil Rashedi. (2017); IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES. Int. J. of Adv. Res. 5 (May). 1468-1474] (ISSN 2320-5407). www.journalijar.com

Ali Souldozi
Faculty of science, Urmia Branch, Islamic Azad University, Urmia, Iran

DOI:

Article DOI: 10.21474/IJAR01/4269      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4269

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