STUDYING THE RELATION BETWEEN IRON DEFICIENCY ANEMIA & FEBRILE SEIZURES.
- Pediatrics Department, Faculty of Medicine, Benha University, Egypt.
- Clinical & Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt.
- Pediatric department, Benha Teaching hospital, Egypt.
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
Objective:The aim of this study was to evaluate iron deficiency anemia as a risk factor for febrile seizures in pediatrics. Background: Febrile seizures are a form of acute symptomatic seizures. Being one of the most important pediatric health problems in developing and developed countries. Also, iron deficiency anemia is a major health problem in young children. Methods:This study was conducted on 80 infants and children aged 6 months to 6 years old. They were divided into two groups: group (A) it included 50 infants and children suffering from febrile seizures with mean age 23.6?15.84; (6-72) months. Group (B): it included 30 infants and children suffering from fever without any neurological problems, with mean age 16.89?13.15; (6-60) months. 25 infants were from rural areas and 25 infants were from urban areas in group (A); while 18 infants were from rural areas and 12 infants were from urban areas in group (B). All enrolled children were subjected to: history taking, clinical examination. Complete blood count was done with measures of serum iron, serum ferritin levels , total iron binding capacity and Transferrin saturation. Results:Iron deficiency anemia was present in 72% of group A (36) and 50% of group B(15). There was statistical significant difference between studied groups regarding the presence of iron deficiency anemia with OR of 2.57 95% CI (0.90-7.34). There was negative significant correlation between temperature and Serum ferritin in Group A, positive significant correlation between temperature and TIBC in Group A and negative significant correlation between temperature and Transferrin saturation in both Group A and Group B. Conclusion: Children with iron deficiency anemia were found to be more susceptible to have febrile convulsions compared to non-anemic children.
- Berg A.T, p. Jallon, and p.m. preux.(2013):"The epidemiology of seizure disorders in infancy and childhood, definitions and classifications" Handbook of Clinical Neurology, Vol. 111 (3rd series), Pediatric Neurology Part I, Chapter 43.
- Susan Amirsalari, Taj K. Zarrin and Mostafa Ahmadi, et al. (2010):"Relationship between iron deficiency anemia and febrile seizures" Iran J Child Neurology; Vol 4: 27-30.No1 June 2010
- Park K. Nutrition and Health in: Textbook of Preventive and Social Medicine. 22nd ed. India: BanarasidasBhanotpublishers publication. 2013;577-578.
- Burtis CA, Edward RA.Principles of colorimetric determination of unsaturated iron binding capacity in serum. In: Burtis CA, Edward RA, David EB, editors. Tietz textbook of clinical chemistry. 4th ed. Philadelphia, Pennsylvania, USA: Elsevier Saunders 2006; 2195?2197.
- McPherson RA, Pincus MR. Iron deficiency anemia: diagnosis and management. In: McPherson RA, Pincus MR, editors. Henry?s clinicaldiagnosis and management laboratory methods. 21st ed. Philadelphia, PA: WB Saunders 2007; 455?482.
- Sipahi T, K?ksal T, Tavil B, Akar N.The effects of acute infection on hematological parameters.PediatrHematolOncol 2004; 21:513?520.
- Akbayram S, Cemek M and Buyukben A, et al. (2012):"Major and minor bio-element status in children with febrile seizure." Bratisl Lek Listy 2012; 113: 421-3.
- Gencer Haşim, İhsan Kafadar, and Gulşen Kose, et al (2016):"Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency" Febrile Convulsion and Elements. JAREM 2016; 6: 947
- Raju M. S. and Kumar M. P.( 2015):"Study of Association between Iron Deficiency Anemia and Febrile Seizure". Journal of Evolution of Medical and Dental Sciences 2015; Vol. 4, Issue 39, May 14; Page: 6818-6823.
- Modaresi M, Mahmoudian T and Yaghini O, et al.( 2012):" Is Iron Insufficiency Associated with Febrile Sei- zure? Experience in an Iranian Hospital." J Compr Ped. 2012;3(1):21-4.
- Vaswani RK, Dharaskar PG and Kulkarni S, et al.(2010):"Iron deficiency as a risk factor for first febrile seizure." Indian Pediatrics. 2010; 47(5): 437-39.
- Chandrasekhar R.V, Sasi Bhushan G and Vijaya Lakshmi B (2016):"Iron deficiency as a risk factor for febrile seizures"NRI ,Medical College, Mangalagiri Road, Chinakakani, Guntur District, Guntur, Andhra Pradesh 522503 April, 2016/ Vol 3/ Issue 4
- Naseer M. R. and Patra C. K. (2015): "Correlation of serum iron and serum calcium levels in children with febrile seizures." International Journal of Contemporary Pediatrics 2015 Nov;2(4):406-410
- Derakhshanfar H, Abaskhanian A and Alimohammadi H, et al.(2012):"Association between iron deficiency anemia and febrile seizure in children." Med Glas (Zenica). 2012;9:239-42.
- Bidabadia Elham and Mashoufb Mehryar (2009): "Association between iron deficiency anemia and first febrile convulsion: A case?control study." Iran Seizure Volume 18, Issue 5, June 2009, Pages 347?351
- Miri-Aliabad G, Khajeh A and Arefi M, et al.(2013): "Iron status and iron deficiency anemia in patients with febrile seizure." Zahedan J Res Med Sci (ZJRMS) 2013; 15(9): 14-17.
- Singh P. and Mehta V. (2016):"Is iron deficiency anaemia a risk factor for febrile seizure? A case control study" International Journal of Contemporary Pediatrics . 2016 Nov;3(4):1307-1311
- Idro R, Gwer S and Williams TN, et al.(2010):" Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis".PLoS One.?2010; 5(11):e14001
- Shah H, Shah B and Banker D , et al (2016): "Study of association of Iron deficiency anaemia and simple febrileseizures in 6-60 months children: A Case control study" Department of Pediatrics/N.H.L Medical College,Gujarat University,India February, 2016/ Vol 3/ Issue 2
- Khurram M.S.A., Reddy U.N. and Mir Sumsam Ali Khurram( 2016):"A study of evaluation of iron deficiency as a risk factor for febrileSeizures" Deccan College of Medical Sciences, Hyderabad, Telangana State, India. November 2016/ Vol 3/ Issue 11
- Malla Tejesh, Kalpana K Malla and Brijesh Sathian, et al. (2015):"Simple Febrile Convulsion and Iron Deficiency Anemia A Co-relation in Nepalese Children"? American Journal of Public Health Research, 2015, Vol. 3, No. 5A, 11-16
- Akbar M. Ali, NIKFAR Roya and KARIMI Babak (2010):"Evaluation of iron status in 9-month to 5-year-old Children with febrile seizures: a case-control study in The south west of Iran" Iran J Child Neurology Vol4 No2 Sep 2010
- kumari pleela, Nair MKC and Nair SM, et al. (2010): "Iron Deficiency as a Risk Factor for Simple Febrile Seizures?A Case Control Study" Indian pediatrics volume 49__january 16, 2012
- Yousefchaijan P, Eghbali A and Rafeie M, et al. (2014):"The relationship between iron deficiency anaemia and simple febrile convulsion in children. " J Pediatr Neurosci. 2014;9(2):110-4.
- Daoud AS, Batieha A and Abu-Ekteish F, et al. (2002):"Iron status: a possible risk factor for the first febrile seizure." Epilepsia. Jul; 43(7):740- 743.
[Elham A. Nawar, MD, Eman R. Abd El Moneim, MD, Hesham A. Eissa, MD and Marwa G. Massoud, MSC. (2017); STUDYING THE RELATION BETWEEN IRON DEFICIENCY ANEMIA & FEBRILE SEIZURES. Int. J. of Adv. Res. 5 (Aug). 2084-2091] (ISSN 2320-5407). www.journalijar.com