06Feb 2018

CYTOGENETICS FINDINGS OF PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN WEST INDIAN REGION.

  • Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza-A, Ring Road, Surat-395001.
  • M.Sc. student from School of Biotechnology and Bioinformatics, D. Y. Patil deemed to be University, New Mumbai-400614.a
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Acute lymphoblastic leukemia (ALL) is one of the most common malignancies in India. Detection of chromosomal abnormalities by conventional karyotyping and Fluorescent in situ hybridization (FISH) plays a very important role in classification and treatment of ALL patients. The aim of this study was to define the frequency and types of chromosomal aberrations in B-ALL patients of West India. In this study, we analyzed bone marrow samples of 35 (18 adults and 17 childhood) West Indian patients with B-ALL using the conventional G-banding and FISH technique. Total 24 patients (68.57%) showed chromosomal alterations, including numerical and/or structural abnormalities. Hyperdiploidy was most common (11.43%) numerical abnormality while the most common fusion oncogenes were BCR-ABL1/t(9;22) in adults (33.33%) and ETV-RUNX1/t(12;21) in children (23.53%). The incidence of 11q23 and t(1;19) were also high than those reported in the previous studies. There was a difference in the prevalence of abnormalities in the current study, maybe due to the geographical variation and/or small sample size.

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[Pankaj Gadhia, Nitisha Parekh, Pratik Chavda, Garima Bhatia and Salil Vaniawala. (2018); CYTOGENETICS FINDINGS OF PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN WEST INDIAN REGION. Int. J. of Adv. Res. 6 (Feb). 563-570] (ISSN 2320-5407). www.journalijar.com

Prof. P.K.Gadhia
S.N.Gene Laboratory and Research Centre, President Plaza-A, Ring Road, Surat-395001

DOI:

Article DOI: 10.21474/IJAR01/6473      
DOI URL: http://dx.doi.org/10.21474/IJAR01/6473

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