25Apr 2019

STUDY OF SERUM CALCIUM, MAGNESIUM AND URIC ACID IN PREECLAMPSIA AND ITS COMPARISON WITH NORMAL PREGNANCY.

  • M.D. Assistant professor, Department of Biochemistry, Sree Balaji medical college and hospital, Chromepet, Chennai ,Tamil Nadu 600044.
  • M.D.Assistant professor, Department of Biochemistry, NRI institute of medical sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh 531162.
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Preeclampsia is one of the common causes of maternal and foetal morbidities and mortalities. Its incidence is 4-8% of pregnancies. Preeclampsia is defined as the triad of hypertension, proteinuria and oedema occurring after 20 weeks gestation in previously normotensive women. Interestingly, variable serum calcium, magnesium and uric acid levels are found in preeclampsia. The data was collected from normal pregnant women and pre-eclamptic women who were admitted in the Department of Obstetrics and Gynaecology. Samples were collected before commencement of medication and were analysed colorimetrically for calcium, magnesium and uric acid. In pre-eclamptic women Serum calcium, Serum Magnesium were found to be significantly lower (p<0.001) and Serum Uric acid was significantly higher (p<0.001) when compared to normal pregnant women. The findings support that Hypocalcaemia, Hypomagnesaemia and Hyperuricemia correlate to preeclampsia.

  1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Text book of Williams obstetrics at Hypertensive disorder in pregnancy 22th ed.New york. McGraw-Hill 2005. p.774.
  2. Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular, and plasma magnesium and calcium concentrations in preeclampsia. Am J Hypertens 2000; 13: 765-9.
  3. Ray J, Vasishta K, Kaur S, Majumdar S, Sawhney H. Calcium metabolism in pre-eclampsia. Int J Gynaecol Obstet 1999; 66: 245-50.
  4. Richard SR, Nelson DM, Zuspan FP. Calcium levels in normal and hypertensive pregnant patients. Am J Obstet Gynecol 1984: 149: 168-71.
  5. Aali S, Khazaeli P, Ghasemi F, Mehdizadeh A. Serum magnesium and calcium ions in patients with severe preeclampsia/eclamsia undergoing magnesium sulfate therapy. Med Sci Monit 2007; 13: 191-4.
  6. Singh J, O?Donovan M, Coulter-Smith SD, Geary M. An audit of the use of magnesium sulphate in severe pre-eclampsia and eclampsia. J Obstet Gynaecol 2005; 25: 15-7.
  7. Kang DH, Finch J, Nakagawa T, Karumanchi SA, Kanellis J, Granger J, et al. Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens 2004; 22: 229-35.
  8. Williams KP, Galerneau F. The role of serum uric acid as a prognostic indicator of the severity of maternal and fetal complications in hypertensive pregnancies. J Obstet Gynaecol Can 2002; 24: 628-32.
  9. Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol 1998; 178: 1067-71.
  10. Sukonpan K, Phupong V. Serum calcium and serum magnesium in normal and preeclamptic pregnancy. Arch Gynecol Obstet 2005; 273: 12-6.

[Chaganti Sridevi and U.V.P.U. Sowjanya. (2019); STUDY OF SERUM CALCIUM, MAGNESIUM AND URIC ACID IN PREECLAMPSIA AND ITS COMPARISON WITH NORMAL PREGNANCY. Int. J. of Adv. Res. 7 (Apr). 1521-1524] (ISSN 2320-5407). www.journalijar.com

Dr U.V.P.U. Sowjanya
Assistant Professor, Department of Biochemistry,NRI institute of medical sciences Sangivalasa Visakhapatnam 531162

DOI:

Article DOI: 10.21474/IJAR01/8977      
DOI URL: http://dx.doi.org/10.21474/IJAR01/8977

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