THE POSSIBLE LINK BETWEEN VITAMIN D LEVELS AND RESTLESS LEG SYNDROME: A HOSPITAL-BASED CASE-CONTROL STUDY FROM KASHMIR, INDIA
- MD Psychiatry, Lecturer at IMHANS-Kashmir (Department of Psychiatry GMC-Srinagar).
- Senior Resident at Department of Psychiatry GMC Anantnag.
- Senior Resident at Department of Psychiatry GMC Srinagar.
- Lecturer Clinical Psychology, at IMHANS-Kashmir (Department of Psychiatry GMC-Srinagar).
- MD Psychiatry, Lecturer at IMHANS-Kashmir (Department of Psychiatry GMC-Srinagar).
- Professor and Head of the Department of Psychiatry (IMHANS-Kashmir) an associated Hospital of GMC Srinagar.
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Background & Objectives: Various pathophysiological mechanisms and risk factors have been identified in patients with restless leg syndrome and there exist other factors also that are yet to be identified and are under-researched. Evidence suggests a possible link between Vitamin D deficiency and Restless leg syndrome.The aim was to study the Vitamin D levels in patients diagnosed with RLS and to find a correlation between Vitamin D and RLS.
Methods: This was a case-control study carried out in the outpatient department of the Institute of Mental Health and Neurosciences Kashmir.A total of 144 subjects were enrolled in the study. Fifty-one were diagnosed cases of RLS and 93 were healthy controls.The Vitamin D levels were analysed by the chemiluminescent immunoassay method in both cases as well as controls.The descriptive statistics were used for various socio-demographic and clinical variables.The data were analysed by chi-square test, t-test and multivariate logistic regression analysis.
Results: The vitamin D levels were significantly low in the RLS group in comparison to the control group. There was a significant correlation between vitamin D levels, vitamin D deficiency and restless leg syndrome (OR= 1.01, p-value 0.005 and OR= 5.40, p-value <0.0001 respectively).
Interpretation &conclusions: Vitamin D levels were low in patients with RLS. This signifies vitamin D may have some role in the pathophysiology of RLS.Vitamin D regulates the nervous system development and function therefore, its use can be considered in the management of RLS when other modalities cannot prove as a promising agent.
[Rehana Amin, Seema Batool, Yuman Kawoos, Masood Maqbool, Altaf Malla and Mohammad Maqbool (2021); THE POSSIBLE LINK BETWEEN VITAMIN D LEVELS AND RESTLESS LEG SYNDROME: A HOSPITAL-BASED CASE-CONTROL STUDY FROM KASHMIR, INDIA Int. J. of Adv. Res. 9 (May). 1362-1367] (ISSN 2320-5407). www.journalijar.com
Governmentb Medical College, Anantnag, J&K, India
India