31Dec 2016

STAT4 (RS7582694) GENE POLYMORPHISM IN A GROUP OF EGYPTIAN FEMALE SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS.

  • Clinical & Chemical Pathology department, Faculty of Medicine, Benha University, Benha, Egypt.
  • Rheumatology department, Faculty of Medicine, Benha University, Benha, Egypt.
  • Quwisna Central Hospital, Ministry of Health,Quwisna, Egypt.
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Systemic lupus erythematosus (SLE) is a chronic complex autoimmune disease. It results from interaction of genetic, environmental and hormonal factors. Genome Wide Association (GWA) studies have proved the association of multiple STAT4 gene polymorphisms with SLE in different populations. Subjects & methods: The study enrolled 50 Egyptian females, classified into 2 groups: 30 SLE patients and 20 apparently healthy individuals. STAT4 gene C>G (rs7582694) polymorphism was analyzed by PCR-RFLP (Polymerase chain reaction - Restriction fragment length polymorphism) technique. Results: The frequency of minor allele C of the STAT4 (rs7582694) polymorphism was higher in SLE patients than control group but with no statistically significant difference between the two studied groups (P=0.518). There was neither association between genotypes and SLE nor SLEDAI activity grades. Conclusion:STAT4 gene C>G (rs7582694) polymorphism is not associated with the predisposition to SLE or disease activity in the studied group of Egyptian SLE patients.


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[Mona El-Toukhy, Ibrahim Rageh, Eman Abdel-Gwad, Amal Fathy, Ola El-Shimi and Marian Roshdy. (2016); STAT4 (RS7582694) GENE POLYMORPHISM IN A GROUP OF EGYPTIAN FEMALE SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS. Int. J. of Adv. Res. 4 (Dec). 1837-1842] (ISSN 2320-5407). www.journalijar.com


Dr. Ola El-Shimi


DOI:


Article DOI: 10.21474/IJAR01/2590      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2590