20Dec 2016

MULTI-THERAPEUTIC ACTIVITY OF BERBERIS LYCIUM ROYLE: A REVIEW

  • Department of Zoology, Bhoj Mahavidhyalaya Bhopal, Barkatullah University, Bhopal (M.P), India.
  • Center for Biodiversity, School for Biosciences and Biotechnology, BGSB University, Rajouri, J&K, India.
  • Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.
  • Department of Biotechnology, Unique College, Bhopal, Barkatullah University Bhopal (M.P), India.
  • Department of Botany, Govt. Beneezar College Bhopal, Barkatullah University, Bhopal (M.P), India.
  • Department of Zoology and Applied Aquaculture, Barkatullah University, Bhopal (M.P), India.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Herbal medicine is getting popularized in developing and developed countries owing to its natural origin. Berberis lycium (Berberidaceae) is an evergreen shrub 2-3 m in height. It is also known as Indian Barberry in English, Kashmal in Hindi and Ishkeen in Urdu. Its local name is Simbulu in District Rajouri in Jammu and Kashmir (J&K), India. Traditionally, Berberis lycium is used by the Tribal peoples in J&K, India, since the time immemorial. The phytochemical investigation showed the presence of alkaloids, tannins, terpenoids, phenols, flavonoids, fats and proteins. Its roots are yellow in colour, rich in alkaloids Berberine etc. Pharmacological investigation has shown that it exhibits antibacterial, antidiabetic, hepatoprotective, pesticidal, antimutagenic, wound healing, anticancer, antimicrobial, antihyperlipidemic and antifungal properties, supporting its traditional uses. Moreover, it has also edible properties. The present review article overview the ethnomedicinal, chemical, nutritional constituents and pharmacological properties of the plant and in this article attempt has been made to summarize the different properties of the plant.


  1. Abidi P. Zhou Y. Jiang JD. and Liu J. (2005): Extracellular signal regulated kinase-dependent stabilization of hepatic low density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler Thromb Vasc. Biol., 25: 2170-6.
  2. Ahmad, M., Alamgeer, and Sharif T. (2009): A potential adjunct to insulin Berberis lycium Croatic 38(1): 13-18.
  3. Ahmad, M., Alamgeer., Chaudhary, MZ., Nadeem, M., Sharif T and Ahmad B. (2008): Hepatoprotective effect of Berberis lycium in hepatotoxic rabbits. Gomal. Uni. J. Res. 24:24.
  4. Ahmed, E., Arshad, M., Ahmad, M., Saeed, M. and Ishaque M. (2004): Ethnopharmacological survey of some medicinal important plants of Galliyat areas of NWFP, Pakistan. Asian J. PI. Sci., 3(4): 410-415.
  5. Ahmed, M., Alamgeer, Sharif, T., Zabta, CHM., and Akbar A. (2009): Effect of Berberis lycium on Lipid Profile in Alloxan Induced Diabetic Rabbits. Ethnobot. Leaflets 13. 702-708.
  6. Ali, MN and Khan, AA. (1978): Pharmacognostic studies of Berberis lycium Royle and its importance as a source of raw material for the manufacture of Berberine in Pakistan, Pak. J. For., 26.
  7. (1976): Wealth of India, Raw Materials, Publications and Information Directorate, SIR New Delhi, Vol. X. 36.
  8. Anwar, AK., Ashfaq, M. and Nasveen, MA. (1979): Pharmacognostic studies of selected indigenous plants of Pakistan, (Peshawar, NWFP, and Pakistan: Pakistan Forest Institute).
  9. Arayne, MS., Sultana, N. and Bahadur, SS. (2007): The Berberis story: Berberis vulgaris in therapeutics. Pak. J. Pharm. Sci., 20:83-92.
  10. Asif, A., Kakub, G., Mehmood, S., Khunum, R., and Gulfraz, M. (2007): Wound Healing Activity of Root Extracts of Berberis lycium Royle in Rats. Phytother. Res. 21: 589-591.
  11. Babbar, O. P., Chhatwal, V.K., and Ray, I.B. (1982): Effect of berberine chloride eye drops on clinically positive trachoma patients. J. Med. Res., 76:83-88.
  12. Bae, E.A., Han, M.J. and Kim, N.J. (1998): Anti-helicobacter pylori activity of herbal Medicines. Pharmaceut. Bull., 21:990-992.
  13. Baquar, SR. (1989): Medicinal and Poisonous plants of Pakistan, Karachi, Pakistan: Printas, 55.
  14. Bruckner, C. (2000): Clarification of the Carpel number in Papaverales, Capparales and Berberidaceae. Botanical Review, 66(2): 155-307.
  15. Cernakova, M. and Kostalova, D. (2002): Antimicrobial activity of berberine-a constituent of Mahonia aquifolium. Folia Microbiol (praha), 47: 375-8.
  16. Chan, M.Y. (1977): The effect of berberine on bilirubin excretion in the rat. Comp. Med. East. West., 5:161-168.
  17. Chand, N., Durrani, FR., Qureshi, MS. and Durrani, Z. (2007): Role of Berberis lycium in reducing serum cholesterol in broilers. Asian-Australasian. J. Ani. Sci. 20(4): 563-568.
  18. Chandra, P. and Purhit, AN. (1980): Berberine contents and alkaloid profile Berberis species from different altitudes, Biochem, Sys, Eco., 8: 379-380.
  19. Chevalier, A. (2001): Encyclopedia of medicinal plants, revised edition. Sydney (AUS): Dorling Kindersley.
  20. Chiou, WF. Yen MH. And Chen, CF. (1991): Mechanism of vasodilatory effect of berberine in rat mesenteric artery. Eur. J. Pharmacol. 204: 35-40.
  21. Choi, M. S., Oh, J. H., Kim, S. M., Jung, H. Y., Yoo, H. S., Lee, Y. M., Moon, D. C., Han, S. B., and Hong, J. T. (2009): Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. J. Oncol., 34: 1221-1230.
  22. Chopra, R.N., Nayar, S.L. and Chopra, I.C. (1996): Glossary of Indian Medicinal Plants". Council of Scientific and Industrial Research, New Delhi.
  23. Choudhary, VP., Sabir, M. and Bhide, VN. (1972): Berberine in Giardiasis. Indian Pediarr, 9: 143-6.
  24. Chueh, W. H. and Lin, J. Y. (2011): Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobase diabetic mice. Agric. Food Chem., 59: 8021-8027
  25. Cui, G. L., Qin, , Zhang,? Y. B., Gong,? Z. W., Ge,? B. X. and Zang,? Y. Q. (2009a): Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. J. Biol. Chem., 284: 28420-28429.
  26. Datta, SC., Nigam, M.C., Virmani, OP. and Siddiqui MS. (1976): Cold process for production of berberine hydrochloride from Berberis Indian for, 139:204.
  27. Gao, L., He, D., Liu, J. H., Yan, W., Gao, S. and Wang, L. (2011a): Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients. Molecules, 16: 9218-9233.
  28. Gao, N., Zhao, T. Y. and Li, X. J. (2011b): The protective effect of berberine on beta-cell lipoapoptosis. Endocrinol. Invest., 34: 124-130.
  29. Gentry, E.J., Jampani, H.B., and Keshavarz-Shokri, A. (1998):? Anti-tubercular natural products: berberine from the roots of commercial Hydrastis canadensis J. Nat. Prod., 61:1187-1193.
  30. Ghosh, AK., Bhattacharyya, FK. and Ghosh, DK. (1985). Leishmania donovani: amastigote inhibition and mode of action of berberine. Exp. Parasitol, 60: 404-13.
  31. Girish C, Koner BC, Jayanthi S, Rao KR, and Rajesh B. (2009). Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice Pradhan. Indian. J. Med. Res. 129:569.
  32. Gosh AK., Bhattacharyya FK. and Ghosh, DK. (1990): Leishmaniadonovani: A mastigote Inhibition and mode of action of Berberine, Exp., Para., 60:404-413.
  33. Gruenwald, J., Brendler, T. and Jaenicke, C. (2000): PDR for herbal medicines. Medical Economics Company, NJ. 313.
  34. Gu, Y., Zhang, Y. F., Shi, Z.,? Li, X. Y., Hong,? J., Chen, J., Gu, W. G., Lu, X., Xu, G. W. and Ning, G. (2010): Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta, 81: 766-772.
  35. Gulfraz, M., Mehmood, S., Ahmad, A., Fatima, N., Praveen, Z. and Williamson, E. M. (2008): Comparison of the antidiabetic activity of Berberis lycium root extract and Berberine in Alloxan-induced Diabetic Rats. Phytotherapy Research, 22, 1208-1212.
  36. Gulfraz, M, Qadir, G, Nosheen, F, and Parveen, Z. (2007): Antihyperglycemic effects of Berberis lycium Royle in alloxan induced diabetic rats, Diabet. Croatic. 36(3):49-54.
  37. Gulfraz, M., Arshad, M., Nayyer, N., Kanwal, N., and Nisar, U. (2004): Investigation for bioactive compounds of Berberis lycium Royle and Justicia adhatoda L., Ethnobot, Leaflets, 1: 51-62.
  38. Hamayun, M., Khan, A. and Khan, MA. (2005): Common medicinal folk Recipes of District Buner, NWFP, Pakistan, Ethnobot. Leaflets 1: 45, SIUC. USA.
  39. Hasnain, N. (2014): Advances in Biomedicine and Pharmacy (An International J. of Biomedicine, Natural products and pharmacy), 1(1): 11-14.
  40. Hostettmann, K., Marston, A. and Maillard, M. (1995): Phytochemistry of plants used in traditional medicine. Clarendon press, Oxford.
  41. Hou, , Tang,? X., Liu,? H. Q., Tang,? J. Q., Yang,? Y., Jing, X. H., Xiao,? Q., Wang,? W., Gou,? X. C. and? Wang,? Z. R. (2011): Berberine induces cell death in human Hepatoma cells in vitro by down regulating CD147. Cancer Sci., 102: 1287-1292.
  42. Huang, Cal. G., Zhong, C.L., Shan, W., Jiang, J. and Bing, J. (2002): Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Res., 106: 223-227.
  43. Huang, Z., Wang, L., Meng, S., Wang, Y., Chen, T. and Wang, C. (2009): Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. J. Cardiol., In Press.
  44. Ikram, IM., Ensanul, Huq, M. and Warsi, SA. (1996): Alkaloids of Berberis Pakistan J. Sci. Ind. Res., 9:343-6.
  45. Imanshahidi, M. and Hosseinzadeh, H. (2008): Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res., 22: 999-1012.
  46. Irshad, H. A., Pervaiz, H. A., Abrar, B. Y., Fahelboum, I., and Awen, Z. S. (2013): Antimicrobial activity of Berberis lycium Root extract. Trakia J. of Sciences, 11(1): 88-90.
  47. Jeong, HW, Hsu, KC, and Lee, JW. (2009): Berberine suppresses pro-inflammatory responses through AMPK activation in macrophages. J. Physiol. Endocrinol. Metabol. 296: 955?964.
  48. Jussieu, A. L. de. (1789): Berberidaceae, nom. Cons. Genera Plantarum, 286.
  49. Kaneda, Y., Tanaka, T. and Saw, T. (1990): Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic culture. Tokai J. Exp., Clin. Med., 15: 417-23.
  50. Kaneda, Y., Torii, M. and Tanaka, T. (1991): In vitro effects of berberine sulfate on the growth of Entamoeba histolytica, Giardia lamblia and Tricomonas vaginalis. Trop. Med. Parasitol., 85:417-425.
  51. Kang, D.G., Sohn, E.J., and Kwon, EK. (2002): Effect of berberine on Angiotensin converting enzyme and NO/cGMP system in vessels. Vacul Pharmacol, 39: 281-6.
  52. Kaur, C. and Miani, SB. (2001): Fruits and vegetables healthy foods for new millennium, Indian Hort. 45(4): 29-32.
  53. Khan, M., Giessrgl, B., Vonach, C., Madlener, S., Prinz, S., Herbaceck, I., H?lzl, C., Bauer, S., Viola, K., Mikulits, W., Quereshi, RA., Knasm?ller, S., Grusch, M., Kopp, B., and Krupitza, G. (2010): Berberine and a Berberis lycium extract inactivate Cdc25A and induce α tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mut. Res. 683: 123-130.
  54. Khan, MA., Jehanzeb, Shafiullah, Malik, SA., and Shafi, M. (2008): Hepatoprotective effects of Berberis lycium, Galium aparine and Pistacia integerrima in carbon tetrachloride (CCL4) treated rats. J. Post Grad. Med. Inst. 22(2): 91-94.
  55. Kong, W.J., Zhang, H. and Song, DQ. (2009): Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism. 58: 109-19.
  56. Kulkarni, S.K. and Dhir, A. (2009): Current investigational drugs for major depression Opi. Invest. Drugs. 18:767?88.
  57. Kulkarni, SK. and Dhir, A. (2007): Possible involvement of L-arginine-nitric oxide (NO)-cyclic guonosine mono-phosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. Eur. J. Pharmacol, 569: 77-83.
  58. Kulkarni, SK. and Dhir, A. (2008): On the mechanism of antidepressant-like action of berberine chloride. Eur. J. Pharmacol, 589: 163-72.
  59. Kuo, CL., Chi, CW. and Liu, TY. (2004): The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett. 203: 127-37.
  60. Lahiri, S.C. (1958): Positive and negative ionotropic effects of berberine on the cats' heart. Biochem. Exper. Med., 18:95.
  61. Lamontagne, J., Pepin, E. and Peyot, M.L. (2009): Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic {beta}-cell at Sub maximal glucose concentrations. Endocrinology, In Press.
  62. Lau, C.W., Yao, X.Q., Chen, Z.Y., KO, W.H. and Haung, Y. (2001): Cardiovascular actions of berberine. Drug. Rev., 19:234-244.
  63. Lau, CW., Yao, XQ. and Chen, ZY. (2001): Cardiovascular actions of berberine. Cardiovasc Drug Rev., 19: 234-44.
  64. Lee, S. Lim, HJ. and Park, HJ. (2007): Berberine-induced LDLR up-regulation involves JNK pathway. Biochem. Biophys Res. Commun, 362: 853-7.
  65. Lee, Y.S., Kim, W.S. and Kim, K.H. (2006): Berberine, a natural plant product, activates AMP activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. 55:2256?2264.
  66. Leet JE., Hussain SF., Minard, RD. and Sharma, M. (1982): Sindamine, Punjabine, and Gilgitine: Three new seco-bisbenzylisoquinolines alkaloids. Heterocycles. 19:2355-60.
  67. Leet, JE., Slango, V., Hussain, SF., and Sharma, M. (1983): Chenabine and Jhelumine: Seco-bisbenzylisoquinolines or simple isoquinoline-benzylisoquinoline dimmers 7. Heterocycles, 20:425-9.
  68. Letasiova, S., Jantova, S., Cipak, L. and Muckova, M. (2006): Berberine - anti-proliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer Lett., 239: 254-262.
  69. LIU, Wei-hua., HEI, Zi-qing., NIE, Hong., TANG Fu-tian, HUANG He-qing, LI Xue-juan, DENG Yan-hui, CHEN Shao-rui, GUO Fen-fen, HUANG Wen-ge, CHEN Feng-ying and LIU, Peiqing. (2008): Berberine ameliorates renal injury in Streptozotocin-induced diabetic rats by suppression of both oxidative stress and Aldose reductase. Med. J., 121:706-712.
  70. Manske, RHF. (1998):The alkaloids: Chemistry and Pharmacology, (San Diego, California: Academic press, INC), 287.
  71. Miana, GA. (1973): Tertiary dihydroprotoberberine alkaloids of Berberis Phytochemistry, 12: 1822-3.
  72. Mohan, M., Pant, C.R. and Angra, S.K. (1982): Berberine in trachoma. J. Opthalmol. 30:69-75.
  73. Nadkarni, KM. (1980): Indian Material Medica, (Bombay, India: Popular Parakashan Depot), 180-190.
  74. Nakamoto, K., Tamamoto, M., Hamada, T. (1995): In vitro study on the effects of trial denture cleansers with berberine hydrochloride. Prosthet. Dent., 73:530-533.
  75. Nandkarni, A.K. (1976): Nadkarni's Indian Materia Medica Popular Prakashan, Pvt. Ltd. Bombay.
  76. Nidaullah, H., Durrani, FR., Ahmad, S., Jan, IU, and Gul, S. (2010): Aqueous extract from different medicinal plants as anticoccidial, growth promotive and immunostimulant in broilers. ARPN. J. Agric. Biol. Sci. 5(1):53-59.
  77. Olmez, E. and Ilhan, M. (1992): Evaluation of alpha-adreno receptor antagonistic action of berberine in isolated organs. Arzneimittelforschung, 42: 1095-97.
  78. Parwardhan, B. and Hopper, ML. (1992): Ayurveda and future drug development. J Altern Complement Med. 3: 9-11.
  79. Sack, RB. and Froehlich, JL. (1982): Berberine inhibits intestinal secretary response of Vibrio cholera and Escherichia coli Infect Immun., 35:471-5.
  80. Sack, RB. and Froehlich, JL. (2000): Berberine- one herb in many ways. Altern Med. Rev., 5: 175-7.
  81. Saha, P., Bhattacharjee, S., Sarkar, A., Manna, A., Majumder, S. and Chatterjee, M. (2011): Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mutagen activated protein kinase pathway in macrophages. Plos One, 6.
  82. Saha, P., Sen, R., Hariharan, C., Kumar, D., Das, P. and Chatterjee, M. (2009): Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigote. Free Radic. Res., 43: 1101-1110.
  83. Serry, T. M. and Bieter, R.N. (1940): A contribution of pharmacology of berberine. Expr. Ther. 69:64-67.
  84. Shah, H., Shad, A. A., Perveen, S., Khattak, S. and Khattak, K. F. (2003): Physicochemical composition of wild medicinal plant Berberis lycium, J. Applied Sci., 3: 370-375.
  85. Sharma, R. Dr. (2003): Medicinal Plants of India; an Encyclopaedia, 33.
  86. Singh, M., Srivastava, S., and Rawat, AKS. (2007): Antimicrobial activities of Indian Berberis Fitoterap. 78: 574-576.
  87. Singh, M., Srivastava, S., and Rawat, AKS. (2009): Antimicrobial Studies of Stem of Different Berberis Nat. Prod. Sci. 15(2): 60-65.
  88. Srivastava, S., Vartica, R., Srivastava, M., Rawat, AKS. and Shanta, M. (2006): Estimation of heavy metals in different Berberis species and its market samples, Env., Monit, Assess., 116: 315-320.
  89. Sun, D. Abraham,s SN. and Beachey EH. (1988): Influence of berberine sulfate on synthesis and expression of Pap fimbrial adhesion in uropathogenic coli. Antimicrob agents. Chemother., 32: 1274-77.
  90. Sun, D., Courtney, H.S. and Beachey, E.H. (1988): Berberine sulfate blocks adherence of Streptococcus pyrogenes to epithelial cells, tibronectin, and hexadecane. Agents. Chemother., 32:1370-1374.
  91. Sun, X., Zhang, X. and Hu, H. (2009a): Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis. , Pharm., Bull., 32:1533-1537.
  92. Sun, X., Zhang, X. D., Hu, H., Lu, Y. N., Chen, J., Yasuda, K. and Wang, H. Y. (2009b): Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis. Pharm. Bull., 32: 1533-1537.
  93. Szeto, S. Yow CMN. and Fung KW. (2002): Characterization of berberine on human cancer cells in culture. Turk J. Med. Sci., 32: 363-8.
  94. Tewary, DK., Bhardwaj, A., and Shanker, A. (2005): Pesticidal activities in five medicinal plants collected from mid hills of western Himalayas. Indus. Crop. Prod. 22: 241-247.
  95. Turner, N., Li, J.Y. and Gosby, A. (2008): Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin function. , 57:1414-1418.
  96. Usmanghani, K., Saeed, A. and Alam, MT. (1997): Indusyunic medicine, (Karachi, Pakistan: University of Karachi press), 120.
  97. Watt, G. (1972): Dictionary of Economic Products of India, Reprinted edition periodical expert. Delhi, Vol. VI (Pt. IV), 83.
  98. WHO, (1977): Resolution-Promotion and development of Training and Research in Traditional Medicine, WHO document, 30-49.
  99. Wong, KK. (1998): Mechanism of the aortic relaxation induced by low concentrations of berberine. Planta. Med. 64: 756-7.
  • Xingshen, Ye., Yibin, F., Yao, T., Kwan-Ming Ng., Saiwah, T., George, K. K., Chowing S., Yanbo Z., Jun T., Jiangang and Seiichi K. (2009): Hepatoprotective effects of Coptidis rhizome aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. J. Ethno, Pharmacol, 124:130-136.
  • Yin, J., Xing, H., Ye J. (2008): Efficacy of berberine in patients with type 2 diabetes mellitus. Med. Rev., 57:712-717.
  • Yuan, J., Shen, XZ. and Zhu, XS. (1994): Effect of berberine on transit time of human small intestine. Zhongguo Zhong Xi. Yi Jie He Za Zhi. 14:718-20.
  • Zaman, MB. and Khan (1970): Hundred drug plants of West Pakistan. (Peshawar, NWFP: Pakistan Forest Institute.
  • Zhang, B. J., Xu, D., Guo, Y., Ping, J., Chen, L. B. and Wang, H. (2008a): Protection by and antioxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. Exp. Pharmacol. Physiol., 35: 303-309.
  • Zhang, Y., Li, X., Zou, D., Liu W., Yang, J., Zhu, N., Huo, , Wang, M., Hong,? J., Wu,? P., Ren,? G. and Ning, G. (2008c): Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J. Clin. Endoc. Metab., 93: 2559-2565
  • Zhou, J. Y., Zhou, S. W., Tang, J. L., Zhang, K. B., Guang, L. X., Huang, Y. P., Xu, Y., Ying, Y., Zhang, and Li, D. D. (2009a): Protective effect of berberine on beta cells in Streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Europ. J. Pharmacol., 606: 262-268
  • Zhou, J. Zhou, S. and Tang, J. (2009b): Protective effect of berberine on b?te cells in Streptozotocin and high-carbohydrate/high-fat diet-induced diabetic rats. Eur. J. Pharmacol., 606: 262-8.s.

[Manik Sharma, Javaid Iqbal, Som Kailash, Mohd Asgher, Mohd Younis, Jagrati Tripathi, Fakhar Shezad and Meraj Ud Din Hura. (2016); MULTI-THERAPEUTIC ACTIVITY OF BERBERIS LYCIUM ROYLE: A REVIEW Int. J. of Adv. Res. 4 (Dec). 2419-2431] (ISSN 2320-5407). www.journalijar.com


Javaid Iqbal
Department of Zoology, Bhoj Mahavidhyalaya Bhopal, Barkatullah University Bhopal, (M.P), India

DOI:


Article DOI: 10.21474/IJAR01/2668      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2668