EFFECT OF SERUM COPPER LEVELS IN TYPE 2 DIABETES MELLITUS WITH NEPHROPATHY: A CASE CONTROL STUDY IN NORTH INDIAN POPULATION.
- Senior Resident, Department of Accident and Emergency Medicine, Lady Hardinge Medical College (LHMC), New Delhi. Senior Resident, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi. Address of correspondence- – Room no. 3013, Department of Biochemistry, Third Floor, Teaching Block, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi-110027. Junior Resident, Department of Pathology, Lady Hardinge Medical College (LHMC), New Delhi. Senior Resident, Department of Gastroenterology, Max Super Specialty Hospital, Saket, New Delhi. Senior Resident, Department of Chest and TB, PGIMS, Rohtak, Haryana. Senior Resident, Department of Pulmonary and Critical care.PGIMS, Rohtak, Haryana. Assistant Professor, Department of Biochemistry, LN Medical College and JK Hospital, Bhopal, MP Professor, Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi. Professor, Department of Medicine, Lady Hardinge Medical College (LHMC), New Delhi.
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Introduction-Diabetes mellitus is chronic metabolic disease, associated with various complications such as diabetic nephropathy. It is most common cause of End Stage Renal Disease (ESRD) in diabetic individual. In various studies, altered levels of serum copper levels are associated with diabetic complications such as diabetic nephropathy. We studied serum copper levels in type 2 diabetic individual with and without nephropathy. Materials and Methods- The study population consisted of 100 type 2 diabetic individual which was further divided into two groups, first group consisted of 50 diabetic individual with nephropathy and second group consisted of 50 diabetic individual without nephropathy. Diabetic nephropathy status was assessed by spot urinary albumin creatinine ratio and GFR. Serum copper levels were measured by colorimetric method. Result- Mean serum copper levels were significantly higher in diabetic patient with nephropathy (111.8 ± 13.9 mg/dl) as compare to diabetic patient without nephropathy (102.3 ± 16.2 mg/dl), (p = 0.002). Serum copper was also positively correlated with weight of subject (r = 0.263, p = 0.009), and negatively correlate with serum zinc (r = -0.263, p = 0.009). Conclusion- Diabetic nephropathy is the leading cause of death in diabetic individual. Our study points toward the increased serum copper levels are associated with diabetic nephropathy. Thus we could use copper chelator in an attempt to decrease serum copper, so that diabetic nephropathy could be prevented and thus improve overall management of diabetic individual.
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[Sonny Bherwani, Ashok Kumar Ahirwar, A S Saumya, Sitendu Kumar Patel, A S Sandhya, Brijesh Prajapat, Srushtee Bipin Jibhkate, Ritu Singh and LH Ghotekar. (2017); EFFECT OF SERUM COPPER LEVELS IN TYPE 2 DIABETES MELLITUS WITH NEPHROPATHY: A CASE CONTROL STUDY IN NORTH INDIAN POPULATION. Int. J. of Adv. Res. 5 (1). 420-424] (ISSN 2320-5407). www.journalijar.com
Article DOI: 10.21474/IJAR01/2762 DOI URL: http://dx.doi.org/10.21474/IJAR01/2762
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