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Tuberculosis caused by Mycobacterium strains intracellular bacilli is a pernicious infection posing global menace to public health. It kills about 2 million people per year worldwide and has been declared as “Global emergency” by WHO. Nano particulate drug delivery systems are suitable for targeting chronic intracellular infections such as tuberculosis. Given the options for oral as well as parenteral therapy the very nature of the disease and its complex treatment urges one to emphasize on the oral route for controlled drug delivery. Treatment of drug susceptible TB continues for a period of 6 – 9 months, while Multi Drug Resistance TB requires rigorous treatment with second line anti-TB drugs that has many unacceptable systemic side effects. These arduous treatment regimens and lack of knowledge regarding the importance of completing the treatment course can cause non-adherence of patient to the medications that remains the most important reason for treatment failure. Targeted drug delivery in the form of nanoparticles holds significance in combating TB bacilli by prolonged and intracellular drug release. Pending are the discovery of more potent anti-tuberculosis drugs, nanotechnology based intermittent chemotherapy provides a novel and sound platform for an onslaught against tuberculosis. The current review discusses the traditional anti-TB drugs and the advantages of targeted delivery of nanoparticles over conventional treatment in terms of efficacy, reduced frequency of dosing, decreased duration of treatment regimens and reduced systemic toxicity.
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[Madiha Nooreen and Uzma Khan. (2017); NANOPARTICLES: NEOTERIC PLATFORM AGAINST MULTI DRUG RESISTANCE TUBERCULOSIS. Int. J. of Adv. Res. 5 (1). 582-593] (ISSN 2320-5407). www.journalijar.com
DECCAN SCHOOL OF PHARMACY
Article DOI: 10.21474/IJAR01/2786 DOI URL: http://dx.doi.org/10.21474/IJAR01/2786
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