20Jan 2017


  • Department of Histopathology and Cytology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
  • Department of Zoology, Facultyof Science, University of Khartoum, Khartoum, Sudan.
  • Department of Pathology, College of Medicine, Tabaha University, Medina Monawarah, KSA.
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Background and Objective:Cytokeratin 20 (CK20) is a widely expressed epithelial protein used as immunohistochemical marker for routine diagnosis. The aim of the current study was to detect the immunohistochemical expression of Ck20 tumor markerin colorectal tumors among Sudanese patients. Methods: Retrospective analytical case control study was conducted at Khartoum state. One hundred and fifty previously diagnosed colorectal tumor blocks were enrolled including 100 malignant tumors and 50benign colorectal tumors. The paraffin sections were tested by immunohistochemical method for CK20 expression. Results: Females were significantly at greater risk of getting colorectal malignant tumors than males (p. value 0.003). Malignant tumors were significantly more common in the rectal site than the colon site (p 0.000). Significant positive immunohistochemical expression of Ck20 was noticed in colorectal malignant tissues (58%) when compared to benign tumors (22%) (p 0.000). Conclusion:The study concluded that colorectal cancer was more distributed in females and the rectal was the most affected site. Immunohistochemical expression of Ck20 in malignant tissues was twice that of benign colorectal tumors confirming the importance of CK20 staining colorectal carcinogenesis regardless of cancer grade.

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[Ahmed Hasan Ahmed Guzailan, Mohammed Siddig Abdal-Aziz, Mai Abdul Rahman Masri and Ahmed Abdelbadie Mohammed. (2017); IMMUNOHISTOCHEMICAL EXPRESSION OF CYTOKERATIN 20 (Ck20) IN COLORECTAL TUMORS AMONG SUDANESE PATIENTS. Int. J. of Adv. Res. 5 (1). 698-702] (ISSN 2320-5407). www.journalijar.com

Ahmed Hasan Ahmed Guzailan
¹ Department of Histopathology and Cytology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan


Article DOI: 10.21474/IJAR01/2801       DOI URL: http://dx.doi.org/10.21474/IJAR01/2801

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