18Feb 2017

GC GLOBULIN GENE POLYMORPHISM: A CANDIDATE LOCUS FOR SUSCEPTIBILITY TO RHEUMATOID AND OSTEOARTHRITIS.

  • Department of Genetics, Osmania University 500007.
  • Salar–E–Millat Research Centre for cellular and Molecular Medicine, PEH, DCMS, Hyderabad India.
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Multiple factors are believed to be involved in the manifestation of Rheumatoid arthritis and Osteoarthritis. Genetic factors are also considered as important predisposing factor in these debilitating conditions. In the present study we investigated the role of Group specific component also known as Gc globulin gene polymorphism in susceptibility to these frequently observed arthritic condition. Gc globulin gene polymorphism was investigated in 115 RA patients, 47 OA cases along with 100 healthy controls. The percentages for Gc 2-2 , Gc 2-1 and Gc 1-1 were 8%, 35% and 57% in the controls. Significantly increased frequency of Gc 2-1 heterozygotes was observed in RA 86.09% and OA 95.74% (*p< 0.05). It is inferred that the individuals with Gc 2-1 globulin have high risk of developing RA or OA compared to those with Gc 2-2 and Gc 1-1.

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[Arshia Fatima, Mohd Ishaq and parveen. (2017); GC GLOBULIN GENE POLYMORPHISM: A CANDIDATE LOCUS FOR SUSCEPTIBILITY TO RHEUMATOID AND OSTEOARTHRITIS. Int. J. of Adv. Res. 5 (Feb). 342-344] (ISSN 2320-5407). www.journalijar.com

Arshia Fatima
Department of Genetics, Osmania University Hyderabad, Telangana-500007

DOI:

Article DOI: 10.21474/IJAR01/3154      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3154

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