22Apr 2017

COMPARATIVE STUDY BETWEEN CHILDREN WITH INTRACTABLE EPILEPSY ON KETOGENIC DIET AND INTRACTABLE EPILEPTIC CHILDREN ON MEDICATION.

  • Professor of Pediatric- Faculty of Medicine - Benha University.
  • Lecturer of Pediatric- Faculty of Medicine - Ain Shams University.
  • Lecturer of Pediatric- Faculty of Medicine - Benha University.
  • Benha Specialized children hospital.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Purpose: to use the regimen of ketogenic diet (modified atkin diet) in addition to anti-epileptic drugs in controlling cases of intractable epilepsy and compare the results with cases receiving anti-epileptic drugs only from one month to 36 months. Subjects and methods: This is a case control study which was performed on 15 cases of refractory epilepsy received anti-epileptic drugs and follow ketogenic diet (modified atkin diet) which are the cases , and 15 patients with refractory epilepsy received antiepileptic drugs only which are the control with age ranging from 1-36 months and mean age(1.63 ? 1.13). Results: showed that, the frequency of convulsions before diet ranged from 2 to 40 with mean 12.4 and standard deviation( SD) 10.769 compared to the frequency of convulsions after diet ranged from 0 to 10 with mean 2.20 and standard deviation 2.95 and there was statistically significant difference between the two groups (P. value was 0.001). There was no statistically significant difference between lipid profile of the patients before diet and after diet. Mean ? standard deviation of Quality Of Life (QOL) scores was 15.71 ? 1.38 before diet which changed to 25.57 ? 3.41 after diet .This difference was statistically significant (P. value was 0.000). Conclusion: Modified atkin diet (MAD) improved patients with intractable epilepsy as regards to frequency of convulsions and quality of life.

  1. El-Rashidy OF, Nassar MF, Abdel-Hamid IA, Shatla RH, Abdel-Hamid MH, Gabr SS, et al.(2009) Modified Atkins diet vs classic ketogenic formula in intractable epilepsy. ActaNeurol Scand. 2013;128:402?408.
  2. Fenton, C., Chee, C.M., Bergqvist, A.G.C., (2009): Manipulation of types of fats and cholesterol intake can successfully improve the lipid profile while maintaining the efficacy of the ketogenic diet. Infant Child Adolesc. Nutr. 1, 338?341.
  3. Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM. (2007): The efficacy of the ketogenic diet-2007: A prospective evaluation of intervention in 150 children. Pediatrics. 2007;102:1358?63.
  4. Go C., Snead C, (2008): Pharmacologically Intractable Epilepsy In Children: Diagnosis and Preoperative Evaluation. Neurosurg Focus.?2008;25(3):E2
  5. Kang HC, Lee HS, You SJ, Kang DC, Ko TS, Kim HD. (2007): Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia 4S:1S2-1S6.
  6. Kossoff EH, (2009):Ketogenic diets: an update for child neurologists. J Child Neurol.; 24(S):979-SS.
  7. Kossoff EH, McGrogan JR. (2005): Worldwide use of the ketogenic diet. Epilepsia.; 46 : 2S0.
  8. Kossoff EH, Zupec-Kania BA, Rho JM. (2009):Ketogenic diets: an update for child neurologists. J Child Neurol.; 24(S):979-SS.
  9. Mar?a J. Alberti, M. Agustinho A, and Argumedo L., (2016) Recommendations for the clinical management of children with refractory epilepsy receiving the ketogenic dietArch Argent Pediatr 2016;114(1):56-63 / 56
  10. Mirjavadi SA, Tonekaboni SH, Ghazavi M, Azargash BE, Abdallah GF, Ghofrani M (2010): Iran journal child neurology vol4; no2.
  11. Stafstrom CE, Rho JM.(2012): The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders. Frontiers in Pharmacology. 2012;3:59. doi:10.3389/fphar.2012.00059.
  12. Stafstrom CE. (2004): An introduction to seizures and epilepsy. In: Stafstrom CE, Rho JM, editors. Epilepsy and the ketogenic diet. Totowa: Humana Press;. ISBN 1-5SS29-295-9.
  13. Suo C, Liao J, Lu X, Fang K, Hu Y, Chen L, et al. (2013): Efficacy and safety of the ketogenic diet in Chinese children. Seizure. 2013;22:174?8.

[Elham Abdel Ghaffar, Yasmin Gamal El Gendy, Eman R.Abd Almonaem and Sara Abdel Heady. (2017); COMPARATIVE STUDY BETWEEN CHILDREN WITH INTRACTABLE EPILEPSY ON KETOGENIC DIET AND INTRACTABLE EPILEPTIC CHILDREN ON MEDICATION. Int. J. of Adv. Res. 5 (Apr). 14-19] (ISSN 2320-5407). www.journalijar.com

sara abdel hady mostafa hussien

DOI:

Article DOI: 10.21474/IJAR01/3776      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3776

Download Full Paper

Download PDF No. of Downloads: 77 | No. of Views: 114