20Mar 2017

DENGUE FEVER IN CHILDREN: ROLE OF ULTRASONOGRAPHY.

  • Junior Resident, Department of pediatrics, Bharati vidyappeth university medical College and Hospital, Sangli.
  • Professor, Department of pediatrics, Bharati vidyappeth university medical College and Hospital, Sangli.
  • Associate Professor, Department of pediatrics, Bharati vidyappeth university medical College and Hospital, Sangli.
  • Assistant Professor Department of pediatrics, Bharati vidyappeth university medical College and Hospital, Sangli.
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Introduction: Dengue fever is one of the most important emerging vector-borne viral diseases. There are four serotypes of dengue viruses, each of which is capable of causing self-limited dengue fever or even life-threatening dengue haemorrhagic fever and dengue shock syndrome. The aim of this study was to evaluate the role of sonographic findings as early diagnostic modality in children with dengue fever. Materials & Methods: This cross-sectional observational study was carried out in the department of pediatrics of a tertiary care hospital. A total of 88 patients who were clinically and serologically (NS1 antigen/ IgM/ IgG antibody) diagnosed as dengue positive were included in this study.These patients also underwent USG abdomen and chest within the first week of the illness. Results: Out of the 88 confirmed dengue cases,56 (63.6%) cases were males. All the cases had fever (100%). Other clinical symptoms were vomiting in 64.8%, abdominal pain in 62.5%,bodyache 53.4%, Shock in 28.4%, headache in48.9% and rashes in 23.9%.The USG findings were hepatomegaly (39.8%), gall bladder thickening (53.4%), splenomegaly (20.5%), pleural effusion (38.6%) and ascites (30.7%).Overall 65 (73.8%) out of 88 cases had one of the positive finding in ultrasonography. Conclusion: Ultrasonography can be used as a first-line imaging modality in all patients with suspected dengue fever to detect early signs suggestive of the disease.

  1. Halstead, S. B.. The XXth century dengue pandemic: need for surveillance and research." World health statistics quarterly. Rapport trimestriel de statistiquessanitairesmondiales. 1992;45(2-3): 292-298.
  2. Jelinek, T., N. Muhlberger, et al. Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop." Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2002; 35(9): 1047-1052.
  3. Nathan Michael B., Dr. DayalRenu-Drager, Guzman Maria.”Epidemiology, Burden of disease and Transmission. WHO Dengue guidelines for diagnosis, treatment, prevention and control, New edition 2009.1: 3-17
  4. Pancharoen C, Kulwichit W, Tantawichien T, Thisyakorn U, Thisyakorn C et al. “Dengue Infection: A Global Concern.” J Med Assoc Thai. 2002;85 (Supp 1): S25 – S3
  5. Innis BL. “Dengue and dengue haemorrhagic fever” In portar field JS, ed. Kass handbook of infectious disease; exotic virus infections, London Chapman and Hall Medical. 1995;103:41-46.
  6. Isturiz RE, Gubler DJ, Brea del Castillo J. (2000) “Dengue and dengue hemorrhagic fever in Latin America and the Caribbean”. Infect. Dis ClinNorth Am. 2000;14:121-40.
  7. Sirivichayakul C. Dengue infection in children in Ratchaburi, Thailand. Clinical manifestations. PLoSNegl Trop Dis. 2012; 6(2):e1520.
  8. Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J. Dengue: A continuing global threat. Nat Rev Microbiol. 2010; 8: S7–16.
  9. Hammond SN, Balmaseda A, Perez L, Tellez Y, Saborio SI. Differences in dengue severity in infants, children, and adults in a 3-year hospitalbased study in Nicaragua. Am J Trop Med Hyg. 2005; 73: 1063–70.
  10. Nieto NC, Khan K, Uhllah G, Teglas MB. The emergence and maintenance of vector-borne diseases in the khyberpakhtunkhwa province, and the federally administered tribal areas of pakistan. Front Physiol. 2012; 3:250.
  11. Watt G, Jongsakul K, Chouriyagune C, Paris R. Differentiating dengue virus infection from scrub typhus in Thai adults with fever. Am J Trop Med Hyg. 2003;68:536–538.
  12. Rahman M, Rahman K, Siddique AK, Shoma S, Kamal AH, Ali KS, et al. First outbreak of dengue haemorrhagic fever, Bangladesh. Emerg Infect Dis 2002; 8(7): 738-740.
  13. Bhamarapravti N. Pathology of dengue haemorrhagic fever. In: Thongcharoen P (ed) Denge/dengue haemorrhagic fever. WHO, Geneva 1993; pp.72-3.
  14. Sai PMV, Dev B, Krishnan R. Role of ultrasound in dengue fever. British Journal of Radiology 2005, 78: 416-418.
  15. Venkata S, Dev B, Krishnan R. Role of ultrasound in dengue fever. Br J Radiol. 2005; 78: 416-418.
  16. Thulkar S, Sharma S, Srivastava DN, Sharma SK, Berry M, Pandey RM et al. Sonographic findings in grade III dengue hemorrhagic fever in adults. J ClinUltrasound 2000; 28: 34-37.
  17. Wu KL, Changchien CS, Kuo CH .Early abdominal sonographic findings in patients with dengue fever. Clin Ultrasound 2004; 32: 386-388.
  18. Statler J, Mammen M, Lyons A, Sun W. Sonographic findings of healthy volunteers infected with dengue virus. J Clin Ultrasound 2008; 36: 413-417.
  19. Nathan Michael B., Dr. DayalRenu-Drager, Guzman Maria.”Epidemiology, Burden of disease and Transmission. WHO Dengue guidelines for diagnosis, treatment, prevention and control, New edition 2009.1: 3-17
  20. Dengue Haemoorrhagic fever: Diagnosis, treatment and controle, Geneva, World Health Organization, 1986.
  21. National Vector Borne Disease Control programme. Annual Report 2014-15.
  22. Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue fever. J Clin Imaging Sci 2014;4:14.
  23. Dengue: Guidelines for diagnosis, treatment, prevention and control. 2009. A joint publication of the World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR).
  24. Martina BEE, Koraka P, Osterhaus ADME. Dengue virus pathogenesis: An integrated view. ClinMicrobiol Reviews. 2009;10:564-81.
  25. Mittal Hema et al. “Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in north India.” Indian J Pediatr., April 2012; volume 79, issue 4: 467-471.
  26. Srinivasa S, Nawab T, Nair CC. Clinical profile and ultasonogaphic findings in children with dengue fever. Current Pediatrics. 2014;18(2).
  27. Dhooria S. et al. “Clinical profile and outcome in children of dengue hemorrhagic fever in north India.” Iran J Pediatr. Sep 2008; vol 18 (No.3): 222-228.
  28. Srivastava VK, Suri S, Bhasin A, Srivastava L, Bharadwaj M. An epidemic of dengue hemorrhagic fever and dengue shock syndrome in Delhi: a clinical study. Ann TropPediatr 1990; 10: 329-334.
  29. Bethell DB, Gamble J, Loc PP, Dung NM, Chau TTH, Loan HT, et al. Non-invasive measurement of microvascular leakage in patients with dengue hemorrhagic fever. ClinInfect Dis 2001; 32: 243-253.
  30. Ahmed FU, Mahmood BC, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengue and Dengue Haemorrhagic Fever in Children During the 2000 Outbreak in Chittagong, Dengue Bulletin 2001; 25: 33-39.
  31. Narayanan M. et al. “Dengue fever epidemic in Chennai- A study of clinical profile and outcome.” Indian Pediatr. 2002; 39: 1027-1033.
  32. Aggarwal Anju et al. “An epidemic of Dengue Hemorrhagic Fever and Dengue Shock Syndrome in children in Delhi.” Indian Pediatr. 1998; 35: 727-732.
  33. Quiroz-Moreno R, Mendez GF, Ovando- Rivera KM. Clinical Utility of ultrasound in the identification of dengue hemorrhagi fever. Rev Med inst Mex SeguroSoc 2006 44(3): 243-348.
  34. Thulkar S, Sharma S, Srivastava DN, Sharma SK, Berry M, Pandey RM et al. Sonographic findings in grade III dengue hemorrhagic fever in adults. J Clin Ultrasound 2000; 28: 34-37.
  35. Setiawan MW, Samsi TK, Pool TN ,Sugianto D, Wulur H. Gallbladder wall thickening in dengue hemorrhagic fever: an ultrasonographic Study. J Cin Ultrasound 1995; 23(6): 357-362.

[Sujit Mulay, C. S. Rajput, Sudha Bhave and Suresh Waydande. (2017); DENGUE FEVER IN CHILDREN: ROLE OF ULTRASONOGRAPHY. Int. J. of Adv. Res. 5 (Mar). 251-256] (ISSN 2320-5407). www.journalijar.com

Dr. Sujit Mulay
Department of Pediatrics, Bharati vidyapeeth university medical college and hospital Sangli

DOI:

Article DOI: 10.21474/IJAR01/3510      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3510

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