22Apr 2017

ANALYTICAL TECHNIQUES TO IDENTIFY SLOW AND FAST ACETYLATORS OF NAT-2 ENZYME USING ISONIAZID.

  • M.Phil (Pharmacology), Pharm-D, Punjab Healthcare Commission. Lahore.
  • MBBS, RHC, Narang Mandi.Shiekhupura.
  • Pharm-D, College of Pharmacy, Lahore Medical & Dental College. Lahore.
  • MBBS, M.Sc (Medical Administration), Punjab Healthcare Commission. Lahore
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Genetic polymorphism significantly affects the therapeutic outcomes of Isoniazid (INH).Various controlled clinical trials have been conducted in India, East Africa, Hong Kong, Singapore, Czechoslovakia, and Britain, which showed that the acetylation phenotype of tuberculosis patients treated with INH is significant, when twice-weekly regimens are given, especially in circumstances in which short initial daily chemotherapy is given. This article will review frequency of slow and fast acetylators in different populations of the world, before illustrating various methods used for the determination of INH and its metabolites used to determine the acetylation phenotype of the individuals. It will also highlight the importance of phenotypic determination on N-Acetyltransferase-2 (NAT-2) during tuberculosis treatment with INH.

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[Sara Sattar, Zain-ul-Abadin, Muzamil Aftab and Anees Qureshi. (2017); ANALYTICAL TECHNIQUES TO IDENTIFY SLOW AND FAST ACETYLATORS OF NAT-2 ENZYME USING ISONIAZID. Int. J. of Adv. Res. 5 (Apr). 307-313] (ISSN 2320-5407). www.journalijar.com

Sara Sattar
Dr. Zain-ul-Abadin

DOI:

Article DOI: 10.21474/IJAR01/3812      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3812

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