22Apr 2017

HEMODYNAMIC INDEXES, REGISTERED IN YOUNG SUBJECTS WITH HIGH NORMAL BLOOD PRESSURE.

  • 1. Department of Physiology, Medical Faculty, Medical University-Plovdiv.
  • 2. First department of internal diseases ? cardiology section, Medical Faculty, Medical University ? Plovdiv.
  • 3. Student 2nd course dental medicine, Dental faculty, Medical University, Plovdiv.
  • 4. Department of internal diseases ? cardiology section, Medical Faculty, Medical University ? Varna.
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The goal of the study was to examine microcirculation and the hemodynamic profile in individuals with high normal arterial pressure (HNAP). The object of the investigation is focused on young individuals from 18 to 35 years with HNAP. The two following groups ? with HNAP and with optimal normal arterial pressure (ONBP) are formed, based on inquiry and screening arterial pressure measurement among 109 individuals (49 men and 60 women). Non invasive native capillaroscopy and anthropometric examination, arterial pressure monitoring and non invasive bio impedance cardiography were carried out. Results: Significantly higher crossed capillaries percentage (22.34?13.07, p< 0.05) is registered in HNAP group compared to the controls ? 16.36?16.64. Cardiac output /cardiac index ratio and velocity index were increased in HNAP, as well as mean arterial pressure. Conclusion: hemodynamic evaluations in HNAP group are close to these in hypertensive individuals.


  1. Ezzati M, Lopez AD, Rodgers A et al (2002). Selected major risk factors and global and regional burden of disease. ,360 (9343):1347-60.
  2. Varsan RS, Larson MG, Leip EP et al (2001). Impact of high-normal Blood pressure on the risk of cardiovascular disease. N Engl J Med., 345: 1291?1297.
  3. Reappraisal of European guidelines of hypertension management. (2009) J Hypertens., 27(11):2121-2158.
  4. Gupta AK, Mc Glone M, Greenway FL et al. (2010). Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile. Hypertens Res., 33: 905-910
  5. Lee M, Saver J, Chang B et al. (2011) Presence of baseline prehypertension and risk of incident stroke - a meta-analysis. Neurology., 77: 1330-1.
  6. Conroy RM, Py?r?l? K, Fitzgerald AP et al.(2003) Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Europ Heart., 24: 987-1003.
  7. He FJ, Mac Gregor G.A (2009). A comprehensive review on salt and health and current experience of worldwide salt reduction programmes. J Hum Hypertens, 23(6):363-84.
  8. Dickinson HO, Mason JM, Nikolson DJ, Compbell F, Beyer FR, Cook JJ, Williams B, Ford GA.(2006) Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials. J Hypertens., 24(2):215-33.
  9. Vita JA, Keaney JF. (2002)Endothelial function a barometer for cardiovascular risk? , 106: 640-642.
  10. Wang Y, Wang Q J (2004). The prevalence of prehypertension and hypertension among US adults according to the new National Joint Committee Guidelines.Arch Int Med., 164 (19): 2126-34.
  11. Gray DS, Fujioka K.(2004) Use of relative weight and Body Mass Index for the determination of adiposity.J Clin Epidemiol., 44 (6): 545?50.
  12. Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ et al.(2010) Body-Mass Index and Mortality among 1.46 Million White Adults. N Engl J Med., 363 (23): 2211?9.
  13. Biopac MP hardware and software manuals.Biopac systems, inc.
  14. Smolle KH, Schmid M, Prettenthaler H, Weger C.(2010) The Accuracy of the?CNAP Device Compared with Invasive Radial Artery Measurements for Providing Continuous Noninvasive?Arterial?Blood Pressure?Readings at a Medical Intensive Care Unit: A Method-Comparison Study.Anesth Analg.,121(6):1508-16.
  15. Fortin J, Marte W, Gr?llenberger R, Hacker A, Habenbacher W, Heller A et al.( 2006) Continuous non-invasive blood pressure monitoring using concentrically interlocking control loops.Computers in biology and medicine., 36(9), 941?57.
  16. Ventura HO, Taler SJ, Strobeck JE.(2005) Hypertension as a?hemodynamic disease: the role of impedance cardiography in diagnostic, prognostic, and therapeutic decision making. Am J Hypertens.; 18: 26?43.
  17. Sanidas EA, Grammatikopoulos K, Anastasiadis G, Papadopoulos D, Daskalaki M, Votteas V(2009). Thoracic fluid content and impedance cardiography: a novel and promising noninvasive method for assessing the hemodynamic effects of diuretics in hypertensive patients. Hellenic J Cardiol., 50(6): 465.
  18. Van De Water JM, Miller TW, Vogel RL, Mount BE, Dalton ML.(2003) Impedance cardiography: the next vital sign technology? Chest., 123:2028.
  19. Ilies C, Bauer M, Berg P, Rosenberg J, Hedderich J, Bein B, Hinz J, Hanss R.(2012) Investigation of the agreement of a continuous non-invasive?arterial pressure?device in comparison with invasive radial artery measurement. Br J Anaest.,; 108(2): 202-10.
  20. Shore AC, Tooke JE.(1994) Microvascular function in human essential hypertension. J Hypererens., 12(7): 717-728.
  21. Struijker ? Boudier HA, le Noble JL, Messing MW et al.(1992) The microcirculation and hypertension . J Hypererens., 10(7): 147-156.
  22. Ingegnoli F, Gualtierotti R, Lubatti Ch, De Angelis R.(2013) Nailfold capillary patterns in healthy subjects: A real issue in capillaroscopy. Res., Nov;90:90-5. Abstract.
  23. Antonios TF, Singer DR, Markandu ND et al.(1999) Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality ". J , 34: 655-658.
  24. Nikolov FP, Nikolov P, Nikolova J. (2011) Prevalence and Risk Profile of Prehypertension in South Bulgaria . International Conference on Prehypertension and Cardio Metabolic Syndrome, 24-27 February , p127.
  25. Wang Y, Wang QJ.(2004) The prevalence of prehypertension and hypertension among US adults according to the new National Joint Committee Guidelines. Arch Int Med., 164 (19):2126-34.
  26. Greenlund KJ, Croft JB, Mensah GA.(2004) Prevalence of heart disease and stroke risk factors in persons with pre hypertension in the United States. Int. Med., 164(19):2113-8.
  27. Elaine M. Urbina, Philip R. Khoury,Connie McCoy, Stephen R. Daniels, Thomas R. Kimball and Lawrence M. Dolan.(2011) Cardiac and Vascular Consequences of Pre-Hypertension in Youth. J Clin Hypertens., (Greenwich). 13(5): 332?342.
  28. O?Rourke M (1995). Mechanical principles in arterial disease. Hypertension; 26(1): 2?9

[Mariana Bacelova, Julia Nikolova, Peter Nikolov, Maria Bacelova and Maria Negreva. (2017); HEMODYNAMIC INDEXES, REGISTERED IN YOUNG SUBJECTS WITH HIGH NORMAL BLOOD PRESSURE. Int. J. of Adv. Res. 5 (Apr). 330-334] (ISSN 2320-5407). www.journalijar.com


Mariana Bacelova
Department of Physiology, Medical University Plovdiv

DOI:


Article DOI: 10.21474/IJAR01/3815      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3815