22Apr 2017

EVALUATION OF BIOMEDICAL IMPORTANCE OF CHLOROGENIC ACID IN THE TREATMENT OF DIABETES MELLITUS IN IN-VIVO ALLOXAN INDUCED DIABETIC RAT MODELS.

  • Punjab Medical College, Faisalabad, Pakistan.
  • Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
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Objective: The present study is designed to investigate the role of Chlorogenic (CGA) acid in the regulation of glucose metabolism in alloxanized diabetic rat models. Method: For the current study, 30 albino rats were divided into five groups. Diabetes was induced by a single intraperitoneal (i.p.) injection of alloxan monohydrate (150mg/kg) in all groups except normal control group. Blood samples were collected at 0 and 28th day of study. Hypoglycemic potential of chlorogenic acid (CGA) was determined. Results: Results of biochemical parameters showed that level of serum glucose and glycosylated haemoglobin was significantly (p <0.05) decreased in CGA treated groups in dose dependent manner along with restored value of serum insulin. While level of serum glucose was observed to decrease significantly after the treatment of CGA. Concentration of serum LDL cholesterol, TC and TG was restored to normal range. While serum HDL cholesterol was raised that was comparable to normal control and glibenclamide treated group. Moreover, oxidative stress parameters and antioxidant profile have shown that CGA possessantihyperglycemic and hypolipidemic properties. Conclusion: Dose dependent antidiabetic activity of CGA was observed.


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[Attiq Ur Rehman, Wafa Majeed, Bilal Aslam, Muhammad Naeem Faisal, Asra Iftikhar and Aisha Sultana. (2017); EVALUATION OF BIOMEDICAL IMPORTANCE OF CHLOROGENIC ACID IN THE TREATMENT OF DIABETES MELLITUS IN IN-VIVO ALLOXAN INDUCED DIABETIC RAT MODELS. Int. J. of Adv. Res. 5 (4). 363-370] (ISSN 2320-5407). www.journalijar.com


Wafa Majeed
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

DOI:


Article DOI: 10.21474/IJAR01/3820       DOI URL: http://dx.doi.org/10.21474/IJAR01/3820


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