15Jun 2017

IMPACT OF METFORMIN AND ITS DURATION OF USE ON SEVERITY OF ISCHEMIC STROKE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.

  • 3rd year MBBS, Govt. Kilpauk Medical College and Hospital.
  • Senior Assistant Professor of Medicine, Govt. Kilpauk Medical College and Hospital.
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Background: Stroke is one of the most devastating neurological conditions. Diabetes mellitus is a well-established independent risk factor for stroke. Metformin therapy reportedly decreases the risk of stroke. But the association between the duration of metformin therapy and the severity of stroke has not yet been assessed. This study aims at assessing the impact of metformin and its duration of use on the severity of ischemic stroke in patients with type 2 DM. Methods: We assessed 60 stroke patients with type 2 DM, without severe renal impairment (serum creatinine < 1.7 mg/dl) who were admitted to Kilpauk medical college hospital between July 2016 and September 2016. Severity of stroke was assessed using NIHSS scale and mRS scale. Results: Metformin therapy was associated with decreased severity of stroke showing improvements in functional outcomes. (p = 0.017, CI ? 95%). In contrast, no significant correlation was found between the duration of metformin use and severity of stroke. Conclusion: Pretreatment with metformin therapy in patients with type 2 diabetes mellitus reduces the severity of stroke. However the correlation between the duration of metformin use and severity of stroke was not significant. Ischemic stroke; Diabetes mellitus; metformin; severity of stroke; NIHSS scale; mRS scale.

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[Alamelu AL and Dhananjayan Kannan. (2017); IMPACT OF METFORMIN AND ITS DURATION OF USE ON SEVERITY OF ISCHEMIC STROKE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. Int. J. of Adv. Res. 5 (Jun). 577-581] (ISSN 2320-5407). www.journalijar.com

Alamelu
M.G.R medical university, Chennai

DOI:

Article DOI: 10.21474/IJAR01/4452      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4452

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