28Jul 2017

OXIDATIVE STRESS, ANTIOXIDANT SCAVENGING SYSTEMS AND DIABETES MELLITUS: A CONCISE REVIEW.

  • Department of Biochemistry, Jinnah University for Women, Karachi ? Pakistan.
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The enormous majority of complex life on earth requires oxygen for its survival. Oxygen is an extremely reactive molecule that damages living organisms by producing reactive oxygen species leading to oxidative stress. Oxidative stress arrived from increasing amount of ROS or as a consequence of increased levels of lipid peroxides and free-radical intermediates, as well as the reduced total antioxidant capacity that may cause the reduction of molecular oxygen or oxidation of water to leads to the formation of free radicals that could damage cellular lipids, membranes, proteins and DNA (Rains et al, 2011). Living organisms have a complex network of antioxidant metabolites and enzymes that work mutually to prevent oxidative damage to cellular components Ido et al, 1997). Advanced oxidative stress and alterations in antioxidant potential, observed in both clinical and investigational diabetes mellitus. Alteration in oxidative stress biomarkers, including Catalase, superoxide dismutase, glutathione, glutathione reductase, glutathione peroxidase, antioxidant vitamins, lipid peroxidation, non enzymatic glycosylated proteins, are helpful in identifying the risk of developing vascular complications in diabetics.

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[Farah Jabeen, Farha Aziz and Husan Afroz Rizvi. (2017); OXIDATIVE STRESS, ANTIOXIDANT SCAVENGING SYSTEMS AND DIABETES MELLITUS: A CONCISE REVIEW. Int. J. of Adv. Res. 5 (Jul). 2205-2216] (ISSN 2320-5407). www.journalijar.com

Farah Jabeen
Chairperson/ Professor Department of Biochemistry Jinnah University for Women, 5-C Nazimabad, Karachi,

DOI:

Article DOI: 10.21474/IJAR01/4961      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4961

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