Association of Interleukin -18 and CD40 in obese polycystic ovary syndrome

This study was designed to examine the association between Interleukin -18, leptin, homocysteine, plasma CD40L levels and insulin resistance in women with obese PCOS and its relationship to endocrine, clinical and metabolic parameters and to know the expanded role of these factors in reproduction might impact our understanding of PCOS. Seventy five women with obese PCOS and fifty healthy, age and body mass index (BMI) matched controls were enrolled in this controlled clinical study. Homocystine,C-reactive protein(hs-CRP),Interleukin-18,Leptin,CD40L,fasting glucose and insulin, homeostatic model assessment insulin resistance index(HOMA-IR),LH,FSH,E2,and Testosterone hormones in addition to ,lipid profile were performed. The levels of homocysteine,Interleukin-18, leptin,CD40L, hs-CRP, fasting insulin and HOMA-IR levels were significantly higher in the obese PCOS group in comparison with the non obese control group(p<0.05). The mean serum triglyceride level in the PCOS group was higher compared with control group (P<0.01), a signifantly increase in levels of homocysteine, sCD40L, hs-CRP, interleukin- 18 Leptin and (HOMA-IR), in obese PCOS patients may be exactly possible to call CD40L associated with hs-CRP a dependent risk factors for cardiovascular disease.This study is the first to assess relation and proathrogenic and proinflammatory markers in obese Iraqi women with PCOS.