SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS.
- Department of Physiology, Benjamin S. Carson Snr School of Medicine, Babcock University, Nigeria.
- Department of Radiology, Babcock University Teaching Hospital, Ilisan, Nigeria.
- Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
A major challenge in diabetic disease is the systemic glucose handling mechanisms with little effort directed at it in the recent past. Spondias mombin is a flowering plant of the anacardiacae family that has been credited with anti-diabetic properties. This study evaluated the anti-diabetic activity of S. mombin, its effects on glucose transporter 4 (Glut-4) and adiponectin receptors signalling in streptozotocin-induced diabetic rats. Adult male Wistar rats (120-160g) were randomly divided into 4 groups. Group 1 were normo-glycemic control rats given regular rat chow and water. Group 2 served as negative hyperglycaemic control. Group 3 (High dose) and Group 4 (low dose) served as treatment groups which were pre-treated with 750mg/kg and 50mg/kg of S. mombin respectively for 21 days. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were done. Glut-4 and adiponectin expression were measured from the supernatant of the gastrocnemius homogenate using ELISA assay. Results were analysed using ANOVA with p<0.05. Results showed that at low doses, S. mombin modulated the glucose handling capabilities of diabetic rats via an insulin-like acting mechanism. S. mombin also significantly elevated adiponectin expression which has a direct correlation with insulin sensitivity. These effects were not magnified in the high dose group. S. mombin failed to potentiate Glut-4 expression in all tested groups. This study showed that the anti-diabetic activity of S. mombin acts via insulin-like mechanism. This is buttressed by the significant increase in adiponectin expression which is a direct correlate of insulin sensitivity.
- Abo K.A., Ogunleye V.O. and Ashidi J.S. (1999): Antimicrobial potential of Spondias Mombin, Croton zambesicus and zygotritonia crocea. Phytotherapy Research., 13, pp 494-497
- Fred-Jaiyesimi A. and Abo K. (2009): Antidiabetic Activity of Spondias mombin Extract in NIDDM Rats. Pharmaceutical Biology., 47:3, 215-218
- Goldstein J. and Rosario S. (2004): Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function. The Journal of Clinical Endocrinology & Metabolism, Volume 89, Issue 6, Pages 2563?2568
- Iweala, E.E.J. and Oludare F.D. (2011): Hypoglycemic effect, biochemical and histological changes of Spondiasmombin Linn. and parinaripolyandrabenth. Seed ethanolic extracts in alloxan-induced diabetic rats. J. pharmacol. Toxicol., 6: 101-112.
- Iwu, M. M. (1993): Handbook of African Medicinal Plants, Boca Raton, 435. CRC Press
- Jang C.,?Inder W.J.,?Obeyesekere V.R. and?Alford F.P. (2008): Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone. Clin Endocrinol.,?69 (5):745-50.
- King H.,?Aubert R.E. and Herman W.H. (1998): Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care., 21(9):1414-31.
- Kokwaro J.O. (1976): Medicinal Plants of East Africa. Nairobi, Kenya: East Africa Literature Bureau. Kampala. p. 384
- LeCaire, T.J. and Palta, M. (2015): Longitudinal Analysis of adiponectin through 20-Year Type 1 Diabetes Duration,??Journal of Diabetes Research., doi: 10.1155/2015/730407
- Ljubic, S., Anamarija, J., and Martina T. (2015): Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria,??International Journal of Endocrinology., vol. 2015. Doi: 10.1155/2015/372796
- Oliver-Bever, B. (1960): Medicinal plants in Nigeria. Being a Course of Four Lectures Delivered in April 1959 in the Pharmacy Department of the Nigerian College of Arts, Science and Technology, Ibadan. p. 760. University of Ibadan press.
- Pari, L., and Amarnath, S. (2004): Antidiabetic activity of Boerhavia diffusa L. effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91,109-113.
- Perseglin, G.,?Guido, L.,?Massimo, D.,?Lucia, P.S.,?Paola, M.,?Francesco De Cobelli,?Alberto, B.,?Antonio, S.,?Alessandro Del Maschio?and Livio, L. (2003): Insulin resistance, intramyocellular lipid content and plasma adiponectin in patients with type 1 diabetes. American Journal of Physiology - Endocrinology and Metabolism.,?Vol.?285?(6):?E1174-E1181
- Sheng, T. and Yang, K. (2008): Adiponectin and its association with insulin resistance and type 2 diabetes. J Genet Genomics.,?35(6):321-6.
[Ajiboye Kolawole, Ogunsola Abimbola O, Agulefo Somto D, Ajayi Etseoghena R, Ajiboye Oyebimpe F and Oluwole Francis S. (2018); SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS. Int. J. of Adv. Res. 6 (Jan). 1334-1340] (ISSN 2320-5407). www.journalijar.com
Department of Physiology, Benjamin S. Carson Snr School of Medicine, Babcock University, Nigeria