13May 2018

ION-SELECTIVE MEMBRANE SENSORS FOR DETERMINATION OF BRIMONIDINE TARTRATE IN BULK POWDER, PHARMACEUTICAL EYEDROPS AND BIOLOGICAL FLUIDS.

  • Faculty of Pharmacy, Damnhour University, Damnhour, Egypt.
  • Department of nanoengineering, University California San Diego (UCSD), La Jolla, CA 92093-0448. USA
  • National organization for drug control and research, (NODCAR), Cairo, Egypt.
  • Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Three novel brimonidine tartrate (BRD) selective electrodes were investigated with di-octyl phthalate as a plasticizer in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using phosphotungestic acid (BRD-PTA), while sensor 2 was constructed using phosphomolybdic acid (BRD-PMA), whereas sensor 3 was constructed using sodium tetraphenyl borate (BRD-TPB) as ionophores. Linear responses of BRD within the concentration ranges of 10−7 to 10−2 mol/l for sensors 1, 2 and 3 were observed. Nernstian slopes of 31.88, 29.83 and 28.50 mv/decade were observed over the pH range of 3-5 for sensors 1, 2 and 3, respectively. The selectivity coefficients of the developed sensors indicated excellent selectivity for BRD. The proposed sensors displayed useful analytical characteristics for the determination of BRD in bulk powder, pharmaceutical formulation and biological fluids (plasma and urine). The novel electrodes offer the advantage of determination of BRD in biological fluids without pretreatment which is convenient for monitoring BRD levels in clinical studies.

  1. Bullock B L(2000) Focus on pathophysiology,Lippincott. New York, p. 1038.
  2. Rang HP, Dale MM (2003) Pharmacology, 6th edition, ElSevier Science Ltd., Churchill LivingStone.
  3. Brimonidine tartrate http://www.drugbank.ca/drugs/db00484.
  4. Rizk MS, Merey HA, Tawakkol SM, Sweilam MN (2014) Simultaneous determination of timolol maleate and brimonidine tartarate in their pharmaceutical dosage form. Anal. Chem. Lett. 4 (2): 132?145. Doi:10.1080/22297928.2014.925825.
  5. Mashru R, Senta B (2014) Development and validation of spectrophotomeric method for simutaneous estimation of brinzolamid and brimonidine tartarate. Asian j. Pharm. Life sci. 4(2) : 16?20.
  6. Ibrahim F, El-Enany N, El-Shaheny RN, Mikhail IE (2014) Validated spectrofluorimetric and spectrophotometric methods for the determination of brimonidine tartrate in ophthalmic solutions via derivatization with nbd-cl . Application to stability study. Luminescence. Doi 10.1002/bio.2730. Doi:10.1002/bio.2730.
  7. Bhagav P, Deshpande P, Pandey S, Chandran S (2010) Development and validation of stability indicating uv spectrophotometric method for the estimation of brimonidine tartrate in pure form, formulations and preformulation studies. Der Pharm. Lett. 2(3): 106?122.
  8. Vijya P, Patel D, Desai S, Meshram D (2014) Development and validation of derivative spectrophotometric method for simultaneous estimation of brimonidine tartarate and brinzolamide in combined dosage form. Indo Am. J. Pharm. Res. 4(3) : 1472?1478.
  9. Popaniya HS, Patel HM (2014) Simultaneous determination of brimonidine tartarate and timolol maleate in combined pharmaceutical dosage form using two different green spectrophotometric methods. World J. Pharm. Pharm. Sci. 3 : 1330?1340.
  10. De Souza JF, Maia KN, Fialho SL, Pereira F, Da Silva GR (2014) Development and validation of spectrophotometric method for the determination of brimonidine into ocular implants. World J. Pharm. Pharm. Sci. 3(3) : 927?941.
  11. Walash M, El-Shaheny R (2016) Fast separation and quantification of three anti- glaucoma drugs by high-performance liquid chromatography uv detection. J. Food Drug Anal. 1?9. Doi:10.1016/j.jfda.2015.11.006.
  12. Sun J, Zhang X, Huang T (2017) A validated stability ‑ indicating hplc method for determination of brimonidine tartrate in bri / phema drug delivery systems. Chem. Cent. J. 11(62) : 1?10. Doi:10.1186/s13065-017-0292-2.
  13. Manoharan G, Al-Bratty M (2016) Development and validation of ultra violet spectrophotometric and reversed-phase high performance liquid chromatography techniques for simultaneous estimation of brinzolamide and brimonidine tartrate in ophthalmic suspension formulation. Orient. J. Chem. 32(2) : 1111?1120.
  14. Madhavi A, Naidu A, Rao DVS, Srinivasu P (2009) Development and validation of a new lc method for analysis of brimonidine tartrate and related compounds. Chromatographia 10 (13) doi:10.1365/s10337-009-1083-2.
  15. Mehta SK, Maheshwari DG (2014) Analytical method development and validation for simultaneous estimation of timolol maleate and brimonidine tartrate in bulk and marketed ophthalmic formulation. J. Pharm. Sci. Biosientific Res. 4 (6): 351?356.
  16. Hassib ST, Elkady EF, Sayed RM (2016) Simultaneous determination of timolol maleate in combination with some other anti-glaucoma drugs in rabbit aqueous humor by high performance liquid chromatography-tandem mass spectroscopy. J. Chromatogr. B. Doi:10.1016/j.jchromb.2016.04.012.
  17. Rizk MS, Merey HA, Tawakkol SM, Sweilam MN (2015) development and validation of a stability-indicating micellar liquid chromatographic method for the determination of timolol maleate in the presence of its degradation products. J. Chromatogr. Sci. 5(3) : 503?510.
  18. Elshanawane AA, Abdelaziz LM, Mohram MS, Hafez HM (2014) Development and validation of hplc method for simultaneous estimation of brimonidine tartrate and timolol maleate in bulk and pharmaceutical dosage form. J. Chromatogr. Sep. Tech. 5(3) : 1?5. Doi:10.4172/2157-7064.1000230.
  19. Anand M, Fonseca A, Ghandi SV, Padmanabh DB (2010) Development and validation of high performance thin layer chromatographic method for estimation of brimonidine tartrate as bulk drug and in ophthalmic solutions. Int. J. Pharmtech res. 2(3) : 1376?1379.
  20. Sonanis MC, Rajput AP (2011) Development and vaidation of a new stability indicating analytical method for the determination of related components of brimonidine tartarate in drug substances and drug product using uplc. Int. J. Pharm. Pharm. Sci. 3 (1) : 145?150.
  21. B?ker E, Din? E (2016) A new uplc method with chemometric design ? optimization approach for the simultaneous quantitation of brimonidine tartrate and timolol maleate in an eye drop preparation. J. Chromatogr. Sci. 1?8. Doi:10.1093/chromsci/bmw160.
  22. Radulovic V, Aleksic MM, Agbaba D, Kapetanovic V (2012) An electroanalytical approach to brimonidine at boron doped diamond electrode based on its extensive voltammetric study. Electroanalysis. 25 (1): 230?236. Doi:10.1002/elan.201200400.
  23. Aleksi MM, Radulovi V, Agbaba D, Kapetanovi V (2013) An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode. Electrochim. Acta. 106 (1) :75?81. Doi:10.1016/j.electacta.2013.05.053.
  24. Radulovi V, Agbaba D, Kapetanovi V, Aleksi MM (2013) An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode, Electrochimica Acta 106 (1): 75?81. Doi:10.1016/j.electacta.2013.05.053.
  25. IUPAC (2000) Analytical chemistry division, Commission on analytical nomenclature. Pure Appl Chem. 72 : 1851.

[H.G. Daabees, Wael Talaat, Manal El-Shal and Kholoud Ahmed. (2018); ION-SELECTIVE MEMBRANE SENSORS FOR DETERMINATION OF BRIMONIDINE TARTRATE IN BULK POWDER, PHARMACEUTICAL EYEDROPS AND BIOLOGICAL FLUIDS. Int. J. of Adv. Res. 6 (May). 120-128] (ISSN 2320-5407). www.journalijar.com

Dr. Kholoud Ahmed

DOI:

Article DOI: 10.21474/IJAR01/7015      
DOI URL: http://dx.doi.org/10.21474/IJAR01/7015

Download Full Paper

Download PDF No. of Downloads: 18 | No. of Views: 67