10Feb 2019

HAEMATALOGICAL EFFECTS OF GASOLINE VAPOUR EXPOSURE BY INHALATION IN THE WISTAR ALBINO RATS.

  • Department of Human Physiology, College of Medical Sciences, University of Maiduguri.
  • Department of Human Anatomy, Kaduna State University.
  • Department of Veterinary Physiology, Faculty of Veterinary Medicine, University of Maiduguri.
  • Department of Human Physiology, University of Jos.
  • Department of Physiology, Faculty of Medicine, Usumanu DanFodio University, Sokoto.
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Aims: This study is to investigate the effect of gasoline vapour exposure on haematological indices in wistar albino rats under simulated work place exposure. Study design: Experimental study Place and Duration of Study: College of Medical Sciences, University of Maiduguri, Borno State, Nigeria betweenFebruary ? September 2010. Methodology: Adult male wistar albino rats were exposed to gasoline vapour in an exposure chamber, with concentration of gasoline vapour maintained at the lower explosive limit 1.4ppm, daily for eight hours, five days a week for six months to simulate the normal working hours. The rats were divided into two groups, group I animals were placed 6cm from the source of the gasoline vapour and group II 150cm from the source. Results: The results show a significant (P< 0.05) increase in red blood cell count (6.68?0.35 and 8.03?0.27) and haemoglobin concentration (11.93?0.29 and 10.95?0.27). There was also a significant rise (p<0.05) in the total leucocyte count (10.58?0.57 and 9.30?0.27) in the exposure group I and II respectively as compared with control group (9.38?0.12). Gasoline vapour exposure at work place has significant effect on haematological indices. Conclusion: The results of this study showed that gasoline vapour exposure has effect on haematological indices, increasing the haemoglobin concentration, packed cell volume, neutrophil count, lymphocyte count, and red blood cells count.


  1. Air Toxics Committee (1989). Evaluation of the Health Effects from Exposure to Gasoline and Gasoline Vapors. Final Report Executive Summary. Northeast States for Coordinated Air Use Management (NESCAUM).
  2. Al-Saggaf,S.M.,Shaker,S.,Ayoub,N.N.,Al-Jahdali,N.H., and Abdel-Hamid,G.A. (2009). Effect of Car Fuel (Gasoline) Inhalation on Trachea of Guinea Pig: Light and Scanning Microscopic Study under Laboratory Conditions. J.Anim.Vet.Adv, 8(11):2118-2124
  3. Chilcott,R.P. (2006). Compendium of Chemical Hazards: Kerosene (Fuel Oil). Health Protection Agency.
  4. Dudhmal, V.B., Sayeda, A., Jadhav, S.S. and Kharadkhedkar, S.S. (2006). Pulmonary Function in Saw Mill Factory Workers. Indian J PhysiolPharmacol 50(3):313-315
  5. Farah,K., Sameer,S., and Tandon, O.P. (2006). Pulmonary Function in Air Conditioner Users. Indian J PhysiolPharmacol 50(1):67-72
  6. KapilSoni, Rakesh Kumar Sharma, Arun Gupta, and VedpalYadav (2016). Impact of Petroleum Fumes on Liverand Kidney Function of Petrol Filling Attendants working in South Haryana, India. European Journal of Pharmaceutical and Medical Research 3(8), 569-573
  7. Kinawy, A.A. (2009). Impact of gasoline inhalation on some neurobehavioral characteristics of male rats. BMC Physiology 9(1):21 http://www.biomedcentral.com/1472-6793/9/21
  8. Mayank,S., Farah, K., Siddarth, S., and Tandon, O. P. (2007).Pulmonary Functions in Petrol PumpWorkers: A Preliminary Study. Indian J PhysiolPharmacol 50(3):244-248
  9. Uboh, F.E., Akpanabiatu, M.I., Eteng, M.U., Ebong, P.E., and Umoh, I.B. (2008). Toxicological Effects of Exposure to Gasoline Vapour in Male and Female Rats. The Internet Journal of Toxicology. Volume 4 Number 2
  10. Uboh, F.E., Akpanabiatu, M.I., Eyong, E.U., Ebong, P.E., and Eka, O.O. (2005).Evaluation of Toxicological Implications of Inhalation Exposure to Kerosene Fumes and Petrol Fumes in Rats. ActaBiologicaSzegediensis. Volume 49 (3-4):19-22.

[Sambo N, D. S. Amaza, Ojo N. A, Odehs.O, Mojiminiyi, F. B. O and S. Sandabe U.K. (2019); HAEMATALOGICAL EFFECTS OF GASOLINE VAPOUR EXPOSURE BY INHALATION IN THE WISTAR ALBINO RATS. Int. J. of Adv. Res. 7 (2). 107-110] (ISSN 2320-5407). www.journalijar.com


Prof. Nuhu Sambo
Baze University Abuja, Department of Human Physiology, College of Medical Sciences, Abuja, Nigeria

DOI:


Article DOI: 10.21474/IJAR01/8466       DOI URL: http://dx.doi.org/10.21474/IJAR01/8466


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