15Apr 2020

ATYPICAL LANGERHANS HISTIOCYTOSIS IN CHILDREN: ABOUT 2 CASES

  • Pediatric Imaging Department, Pediatric Teaching Hospital-Rabat-Morocco.
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Langerhanshistiocytosis is a rare disorder with a heterogeneous clinical presentation. It is characterized by an abnormal proliferation of Langerhans cells in different tissues.The clinical manifestations depend on the number of lesionsand their extension to the soft tissues.The organs affected by the disease, besides the head and the neck, may be the skin, long bones and the digestive system. Imaging confirms osteolytic lesions. The definitive diagnosis is made by biopsy with histological study.


  1. Dhouib M, Triki N, Karray F, Khabir A, Boudaoura T, Abdelmoula M. Histiocytose langerhansienne mandibulaire. Revue de Stomatologie et de Chirurgie Maxillo-faciale. 2006107(6):465-9.
  2. Humberto B.F, Ronaldo C.G, Jacinto N.J. Langerhans Cell Histiocytosis in Otorhinolaryngology. Intl. Arch. Otorhinolaryngol. V.13, n 4, P 444-449. 2009
  3. Kermani et al. Syndrome cochl?ovestibulaire r?v?lateur d\'une histiocytose X avec atteinte de l\'os temporal.St?phan J-L. Histiocytoses langerhansiennes et non langerhansiennes. Archives de p?diatrie. 20029(9):934-41.
  4. Imrani, O.Ayouche, N.Allali, L.Chat. An overlooked case of mandibular histiocytosis: Case report and review of the literature.Int J Case Rep Images 20189.
  5. Lahmar et al. Histiocytose Langerhansienne multivisc?rale avec atteinte auriculaire bilat?rale: A propos d\'une observation. J.TUN ORL-N?19 D?cembre 2007.
  6. Ilknur Haberal Can et al. Mandibular manifestation of Langerhans cell histiocytosis in children.Oral Oncology EXTRA (2005) 41, 174-177.
  7. Hwang DS, Lee JS, Kim UK, Park HR, Ryu MH, Lee JH et al.Langerhans cell histiocytosis of the mandible: two case reports and literature review. J Korean Assoc Oral Maxillofac Surg 201945:167-72.
  8. Xiaping Yi, Tong Han, Hongyan Zai, Xueying Long, Xiaoyi Wang, Wenzheng Li. Liver involvement of Langerhans cell histiocytosis in children. Int J Clin Exp Med 20158(5): 7098-7106.
  9. Zaveri J, La Q, Yarmish G, Neuman J, More than just Langerhans cell histiocytosis: A radiologic review of histiocytic disorders. Radiographics 2014 34(7): 2008-24.
  10. Brodbent V, Gadner H. Current therapy for Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998 12(2):327-38.

[K. Imrani, S. Amalik, N. Allali, S.El Haddad and L. Chat (2020); ATYPICAL LANGERHANS HISTIOCYTOSIS IN CHILDREN: ABOUT 2 CASES Int. J. of Adv. Res. 8 (Apr). 96-101] (ISSN 2320-5407). www.journalijar.com


Imrani Kaoutar
Rabat Children’s hospital, Mohamed V University, Rabat, Morocco

DOI:


Article DOI: 10.21474/IJAR01/10750      
DOI URL: http://dx.doi.org/10.21474/IJAR01/10750