Rapid Malignant Transformation of Low Grade Astrocytoma

Abstract: Astrocytomas are group of tumors which arise from neoplastic transformation of astrocytes or committed astroglial progenitors. It includes slow growing tumors such as fibrillary astrocytoma or very malignant glioblastoma multiforme. Low grade astrocytomas have been documented to undergo transformation into high grade astrocytoma & the time interval ranges from 4 months to more than 5 years.This report is a case of 52 year old male presenting with rapid[11 weeks]malignant transformation of low grade astrocytoma to high grade astrocytoma-glioblastoma multiforme . CT scan showed right sided fronto-temporal brain tumor, craniotomy & surgical resection of the lesion was done. Tissue was sent for histopathological examination. Histopathological examination earlier showed low grade astrocytoma & later transformed into high grade astrocytoma-glioblastoma multiforme with glomeruloides. Low grade glioma can undergo malignant transformation. It was concluded that histologically confirmed low grade astrocytoma underwent rapid evolution,in less than 4months time into high grade astrocytoma.

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[Nishi Tandon, Sumaiya Irfan, A.N.Srivastava, Apoorva Kumar (2015); Rapid Malignant Transformation of Low Grade Astrocytoma Int. J. of Adv. Res. 3 (4). 0] (ISSN 2320-5407). www.journalijar.com

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