CHEMICAL PERMEATION ENHANCEMENT THROUGH SKIN
- Master of Pharmacy student, Pharmaceutical Department, Dr. L. H. Hiranandani college of Pharmacy, Ulhasnagar, Maharashtra, India.
- Assistant Professor, Pharmaceutical Department, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra, India.
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Skin is a major organ for application of drug both for local and systemic effects. However in skin, the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging development that would increase the number of drugs available for transdermal administration. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, skin penetration enhancement approaches have been discussed in order to improve bioavailability and increase the range of drugs for which topical and transdermal delivery is a viable option. Chemical penetration enhancers that aid absorption of co-administered moieties are currently believed to improve solubility within the stratum corneum or increase lipid fluidity of the intracellular bilayers.
[Bashay Masarrat Gulam Ahmed, Singh Sushma (2015); CHEMICAL PERMEATION ENHANCEMENT THROUGH SKIN Int. J. of Adv. Res. 3 (Aug). 644-651] (ISSN 2320-5407). www.journalijar.com
