Design Space Filling Model, Synthesis and Evaluation of Novel 2-Indolinone HIV-1 Inhibitors

Weed out HIV from all of its hiding places within the body is difficult. The approach can be used in bioinformatics practices, including complex binding energy estimation in novel HIV-1 inhibitors. Here we show how a space filling model-based approach used infection HIV-1 inhibitors and role of target compound located insight into the host cell machinery. Process technology by parallel synthesizer major was used for the purposes of synthesized 2- Indolinones potential derivatives. In vitro anti-HIV-1 activity of target compound 8-methoxy-5-(morpholin-4-ylmethyl)-4,4a,5,9b-tetrahydro-1H-pyrazino[2,3-b]indole-2,3 dicarbonitrile (1b) and studies have suggested that above is a novel reservoir has very low cytotoxicity (CC50>1mM) and it has been displays 15.5 ug/ml to cell lines, TZM-bl. Also it displayed potent anti-HIV-1 activity and found 3.96 µg/ml against laboratory adapted strains UG070,7 th PID.