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Methods: 30 hypertensive diabetic subjects of type II (18 males and 12 females) with an average age of (55 ?15 years) and average weight (61 ?16.5 kg) were participated in this study. 17 subjects were on Captopril therapy (50mg/daily) and 13 subjects were on Atenolol therapy (50mg/daily). 30 healthy volunteers of comparable age (52 ? 15 years ) and an average weight (85.5?15.5 kg) was used as control sample. Two venous blood samples were collected from each subject, first blood sample was taken before drug therapy and the second blood sample was taken three weeks after drug therapy. Objectives: In vivo study was carried out to monitor the effect of antihypertensive drugs (Captopril and Atenolol) on the metabolites and enzymes that are requested for professional diagnosis in diabetic patients. Results: Captopril therapy significantly elevated Total protein (TP), Creatinine, Total cholesterol, Triglyceride, and Creatine kinase (CK) whereas Total bilirubin (T.bil.) was significantly reduced. Total cholesterol (T.Chol.), Triglyceride (TG) and Alanine transaminase (ALT) were found significantly increased in patients with Atenolol therapy. Conclusion: Among the antihypertensive drugs, Atenolol has less effect on all biochemical laboratory parameters and therefore it is more favorable than Captopril.
[Mohamad A Alblihed and Husni S. Farah. (2016); Effect of oral Hypertensive agents on Biochemical parameters in Diabetic patients : In vivo study. Int. J. of Adv. Res. 4 (Apr). 963-967] (ISSN 2320-5407). www.journalijar.com
Article DOI: 10.21474/IJAR01/199
DOI URL: http://dx.doi.org/10.21474/IJAR01/199
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