The Effect Of TNF-? , IL-8 In Pathogenesis Of Hepatitis C Virus Patients.

The hepatitis C virus (HCV) is amajor cause of liver disease that infect approximately 130 million people worldwide and can lead to chronic liver disease , cirrhosis and hepatocellular carcinoma (HCC), the aim of the study was to find out if hepatitis C infection influenced the levels of interleukine (IL-8) and Tumor necrotic factor (TNF-?) in liver disease patients.Atotal of (1126) patients were involved in this study.The levels of cytokines in serum of HCV positive was measured by commercial ELISA Tests.Results showed positive for anti- HCV Abwere 84(7.46%) out of 1126 cases including22 (26.19%) for clinical isolates , 5 (5.95%) for dialysis patients , 26 (30.95%) for thalassemia patients and 31 (36.90%) for blood donors patients . Our results showed significant differences in serum level of IL-8 (p<0.05) and (TNF-?) (p<0.001) between investigated groups .Results of cytokines were significantly related with histopathological changes of liver biopsis ,there is scattered inflammatory cell infiltration and marked portal fibrosis for liver tissues.