Evaluation of Lipid peroxidation Marker (MDA), C - reactive protein, and leucocytes indices as Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

This study compared the Malondialdehyde (MDA) as lipid peroxidation marker, high-sensitive C reactive protein (hs-CRP), and leucocytes indices as inflammatory markers between type 2 diabetic patients and healthy controls. This study indicates that hyperglycemic induced elevation in Lipidperoxidation marker (MDA) and inflammatory markers hs-CRP and leucocytes indices, in type 2 DM could supportive in prognosis of vascular complications in patients with diabetes. This study was conducted on 30 Type 2 Diabetic patients and 30 age and sex matched healthy control subjects. Fasting blood glucose (FBG), Glycosylated hemoglobin (HbA1c), hs-CRP level and leucocytes indices including white blood cells count (WBCs), Percentage and Number of Lymphocyte, Monocytes and Granulocytes were estimated and compared with normal subjects. The results were evaluated statistically. The study demonstrated that FBG, HbA1c, hs-CRP, MDA, WBCs and # of Granulocytes were significantly higher in the diabetic patients as compared to controls (P< 0.05). Positive correlation of FBG with HbA1c (r = 0.512, P = 0.004), FBG with hs-CRP (r = 0.498, P = 0.005) was found in diabetic patients. The elevated levels of MDA and hs-CRP along with leucocytes indices are surrogate markers of inflammation, may be used in finding the degree of developing complications, caused by hyperglycemic induced oxidative stress and Lipid peroxidation in type 2 DM .