To assess the frequency of hyperlipidemia in patients with psoriasis and compare its levels with healthy controls in an outpatient of a tertiary care hospital.

Objective of the study: To assess the frequency of hyperlipidemia in adult patients with psoriasis attending dermatology outpatient of a tertiary care hospital. To compare the lipid levels of patient with Psoriasis and healthy volunteers attending the OPD for other conditions. Methods: This was a case control study enrolled patient suffering from Psoriasis for one year and conducted in Dow University Hospital. 100 subjects were enrolled in the study by using convenient sampling, after ensuring inclusion, exclusion criteria and giving informed consent. Statistical analysis was carried out using SPSS-16 to calculate frequency and percentages. Subjects with no known association of lipid metabolism and negative family history of Psoriasis enrolled as healthy controls. Results: Out of 100, 50% were females and 50% were males with psoriasis and in control group 52% were females and 48% were males. Subjects with different psoriatic variants enrolled to assess hyperlipidemia while in control group patient with skin conditions other than Psoriasis or healthy people were enrolled, 39 subjects reported positive family history, subjects with duration of Psoriasis from minimum time recorded 3 months and maximum 18 years, subjects with different sites of involvement enrolled, 47 subjects reported Nail Involvement, 23 patient reported Joint Involvement and 54 patient reported Scalp Involvement, 51 reported mild and 49 reported moderate BSA involvement. Lipid profile differed in subjects with psoriasis when compared with control group. In this study after statistical analysis the results found to be: Cholesterol: mean value of 181 mg/dL for Psoriatics and in Health controls a mean value of 127 mg/dL. LDL: Psoriatics had a mean value was 106mg/dL and in Healthy controls mean value was 74 mg/dL. HDL: A mean value of 45 mg/dL for Psoriatic subjects and mean value of 42 mg/dL in healthy controls. TGS: The mean value of 123mg/dl in Psoriatics while controls had mean value of 94 mg/dL. Conclusions: Hyperlipidemia is a modest finding in psoriasis than control group. It is considered as a risk factor for other co-morbidities like cardiovascular diseases in patients with Psoriasis. Awareness among physicians regarding this problem may help in prevention of serious consequences.